Results 81 to 90 of about 3,661,970 (379)

The toxicity assessment of extract of Peganum harmala L. seeds in Caenorhabditis elegans

BMC Complementary Medicine and Therapies, 2020
Background Peganum harmala L. is a medicinal herb extensively used in traditional Chinese medicine (TCM). So far, relevant reports on the toxicity of Peganum harmala L. seeds (PHS) are hardly available.
Xiangzhen Miao, Xiao Zhang, Yanyan Yuan, Yali Zhang, Jian Gao, Nianxin Kang, Xinkui Liu, Jiarui Wu, Yonggang Liu, Peng Tan   +9 more
doaj   +1 more source

When complexity science meets implementation science: a theoretical and empirical analysis of systems change

BMC Medicine, 2018
BackgroundImplementation science has a core aim – to get evidence into practice. Early in the evidence-based medicine movement, this task was construed in linear terms, wherein the knowledge pipeline moved from evidence created in the laboratory through ...
J. Braithwaite, K. Churruca, Janet C. Long, L. Ellis, J. Herkes   +4 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Ontology as the core discipline of biomedical informatics: Legacies of the past and recommendations for the future direction of research [PDF]

, 2007
The automatic integration of rapidly expanding information resources in the life sciences is one of the most challenging goals facing biomedical research today.
Ceusters, Werner, Smith, Barry
core  

Altering the inhibitory kinetics and molecular conformation of maltase by Tangzhiqing (TZQ), a natural α-glucosidase inhibitor

BMC Complementary Medicine and Therapies, 2020
Background Tangzhiqing (TZQ), as a potential α-glycosidase inhibitor, possesses postprandial hypoglycaemic effects on maltose in humans. The aim of this study was to investigate the mechanisms by which TZQ attenuates postprandial glucose by interrupting ...
Yanfen Li, Xiaomao Zhang, Ruihua Wang, Lu Han, Wei Huang, Hong Shi, Baohe Wang, Ziqiang Li, Shaolan Zou   +8 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

PAMs inhibits monoamine oxidase a activity and reduces glioma tumor growth, a potential adjuvant treatment for glioma

BMC Complementary Medicine and Therapies, 2020
Background Monoamine oxidase (MAO) A catalyzes oxidative deamination of monoamine neurotransmitters and dietary amines and regulates brain development and functions.
Pei-Chuan Li, Shih-Yi Chen, Danzhou Xiangfei, Canquan Mao, Chieh-His Wu, Jean Chen Shih   +5 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Controlled surface initiated polymerization of N-isopropylacrylamide from polycaprolactone substrates for regulating cell attachment and detachment [PDF]

, 2012
Poly(ε-caprolactone) (PCL) substrates were modified with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) brushes to direct and control cellular attachment and detachment. Prior to brush growth, the surface of PCL was activated by a diamine to allow
Blitterswijk, C.A. van, Di Luca, A., Klein Gunnewiek, M., Moroni, L., Sui, X., Vancso, G.J.   +5 more
core   +3 more sources

Analysis of microRNA expression in peripheral blood monocytes of three Traditional Chinese Medicine (TCM) syndrome types in psoriasis patients

Chinese Medicine, 2020
Background To analyze the expression of miRNA (microRNA) in peripheral blood mononuclear cells in patients with Psoriasis vulgaris with different TCM syndromes by miRNA chip.
Yue Lu, Yao Qi, Yuhong Yan, Danni Yao, Hao Deng, Jingwen Deng, Shuyan Ye, Haiming Chen, Qubo Chen, Hengjun Gao, Ling Han, Chuanjian Lu   +11 more
doaj   +1 more source