Results 151 to 160 of about 24,961 (203)
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Cisplatin-induced ototoxicity: updates on molecular mechanisms and otoprotective strategies.
European journal of pharmaceutics and biopharmaceutics, 2021Cisplatin is a highly effective antitumor drug generally used in the treatment of solid malignant tumors. However, cisplatin causes severe side effects such as bone marrow depression, nephrotoxicity, and ototoxicity, thus limiting its clinical ...
Qing Tang +7 more
semanticscholar +1 more source
Journal of Neurophysiology, 2021
Cisplatin is an anti-tumor drug which is widely used for treatment of various solid tumors. Unfortunately, patients are often troubled by serious side effects, especially hearing loss. Up to now, there have been no clear and effective measures to prevent
Zhengrong Liang +6 more
semanticscholar +1 more source
Cisplatin is an anti-tumor drug which is widely used for treatment of various solid tumors. Unfortunately, patients are often troubled by serious side effects, especially hearing loss. Up to now, there have been no clear and effective measures to prevent
Zhengrong Liang +6 more
semanticscholar +1 more source
Annals of Otology, Rhinology & Laryngology, 1978
A case of oral neomycin ototoxicity is presented, followed by a summary of known cases in the English literature. While it is known that neomycin is concentrated in the inner ear fluids, at the present time the biochemical basis of its ototoxic effect has not been definitively elucidated. High frequency audiometry can aid in the early detection of the
K M, Ward, F J, Rounthwaite
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A case of oral neomycin ototoxicity is presented, followed by a summary of known cases in the English literature. While it is known that neomycin is concentrated in the inner ear fluids, at the present time the biochemical basis of its ototoxic effect has not been definitively elucidated. High frequency audiometry can aid in the early detection of the
K M, Ward, F J, Rounthwaite
openaire +2 more sources
Current Opinion in Otolaryngology & Head & Neck Surgery, 2007
To summarize mechanisms of ototoxicity associated with aminoglycoside antibiotics and discuss possible protective strategies.Studies in the past 15 years have demonstrated that aminoglycoside ototoxicity is mediated by an apoptotic form of cell death which employs caspase-dependent pathways. Reactive oxygen species have been demonstrated in the sensory
Mark Douglas, Rizzi, Keiko, Hirose
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To summarize mechanisms of ototoxicity associated with aminoglycoside antibiotics and discuss possible protective strategies.Studies in the past 15 years have demonstrated that aminoglycoside ototoxicity is mediated by an apoptotic form of cell death which employs caspase-dependent pathways. Reactive oxygen species have been demonstrated in the sensory
Mark Douglas, Rizzi, Keiko, Hirose
openaire +2 more sources
In silico prediction of drug‐induced ototoxicity using machine learning and deep learning methods
Chemical Biology and Drug Design, 2021Drug‐induced ototoxicity has become a serious global problem, because of leading to deafness in hundreds of thousands of people every year. It always results from exposure to drugs or environmental chemicals that cause the impairment and degeneration of ...
Xin Huang +3 more
semanticscholar +1 more source
American Journal of Otolaryngology, 1980
Aminoglycoside antibiotics are frequently employed in the treatment of serious infections caused by aerobic gram negative bacilli. The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the serum concentration. Impaired renal
S A, Lerner, G J, Matz
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Aminoglycoside antibiotics are frequently employed in the treatment of serious infections caused by aerobic gram negative bacilli. The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the serum concentration. Impaired renal
S A, Lerner, G J, Matz
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Annals of Otology, Rhinology and Laryngology, 2021
Objectives: Teprotumumab, a novel monoclonal antibody, targets the insulin-like growth factor 1 (IGF-1) receptor. IGF-1 receptors, found in muscle and fat adjacent to the eye and implicated in Graves Ophthalmopathy, are also in the cochlea.
Julie Highland +3 more
semanticscholar +1 more source
Objectives: Teprotumumab, a novel monoclonal antibody, targets the insulin-like growth factor 1 (IGF-1) receptor. IGF-1 receptors, found in muscle and fat adjacent to the eye and implicated in Graves Ophthalmopathy, are also in the cochlea.
Julie Highland +3 more
semanticscholar +1 more source
Clinical Rheumatology, 2007
Chloroquine (CQ), a 4-aminoquinoline drug, has been largely used for the treatment of rheumatoid arthritis and other connective tissue diseases. Besides the well-known retinal toxicity, its use has been suspected of be associated to ototoxicity.
Rodrigo, Bortoli, Mittermayer, Santiago
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Chloroquine (CQ), a 4-aminoquinoline drug, has been largely used for the treatment of rheumatoid arthritis and other connective tissue diseases. Besides the well-known retinal toxicity, its use has been suspected of be associated to ototoxicity.
Rodrigo, Bortoli, Mittermayer, Santiago
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International Journal of Pediatric Otorhinolaryngology, 2021
OBJECTIVES Aminoglycoside-induced cochlear ototoxicity causes inner ear hair cells (HCs) loss and leads to hearing impairment in patients, but no treatment completely eliminates the ototoxic effect.
Yulong Zong +3 more
semanticscholar +1 more source
OBJECTIVES Aminoglycoside-induced cochlear ototoxicity causes inner ear hair cells (HCs) loss and leads to hearing impairment in patients, but no treatment completely eliminates the ototoxic effect.
Yulong Zong +3 more
semanticscholar +1 more source
Veterinary Clinics of North America: Small Animal Practice, 1994
This article describes the pathophysiology of ototoxic agents and contains a list of potential ototoxic agents including a list of animal species in which the toxicity has been documented or research studies performed.
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This article describes the pathophysiology of ototoxic agents and contains a list of potential ototoxic agents including a list of animal species in which the toxicity has been documented or research studies performed.
openaire +2 more sources