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From Ototoxicity to Otoprotection: Mechanism and Protective Strategies in Cisplatin Therapy. [PDF]

open access: yesPharmaceuticals (Basel)
Iațentiuc A   +11 more
europepmc   +1 more source
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Ototoxicity and Teprotumumab

Annals of Otology, Rhinology & Laryngology, 2021
Objectives: Teprotumumab, a novel monoclonal antibody, targets the insulin-like growth factor 1 (IGF-1) receptor. IGF-1 receptors, found in muscle and fat adjacent to the eye and implicated in Graves Ophthalmopathy, are also in the cochlea.
Julie Highland   +3 more
openaire   +2 more sources

Carboplatin is ototoxic

Cancer Chemotherapy and Pharmacology, 1990
For assessment of the ototoxic potential of carboplatin [cis-diammine-1,1-cyclobutane dicarboxylate platinum(II); CBDCA], pure-tone audiograms were evaluated in 27 patients receiving a total of 119 doses of carboplatin in the range of 300-400 mg/m2.
I C, Kennedy   +3 more
openaire   +2 more sources

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