Results 11 to 20 of about 40,713 (239)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Endometriosis-associated pain and new therapeutic options: A review [PDF]

Гинекология, 2023
Pelvic pain is one of the most common and significant clinical symptoms of endometriosis. The complex pathogenesis and paradoxical nature of endometriosis-associated pain, its chronicity and centralization, a marked decrease in the quality of life of ...
Maria I. Yarmolinskaya, Alexandra K. Beganova, Anastasia S. Revenko   +2 more
doaj   +1 more source

A STUDY ON THE CONSUMPTION PATTERN AND VIEWER EXPERIENCE OF OTT PLATFORMS WITH SPECIAL REFERENCE TO ERNAKULAM CITY [PDF]

Proceedings on Engineering Sciences
Over-The-Top (OTT) streaming services distribute online audio-visual content, including music. These platforms don't make use of the typical cable or satellite feeds as traditional television does.
T J Rejo , V. Ramadevi
doaj   +1 more source

Una mirada epistemológica sobre el costo de los nuevos bienes de capital

Contabilidad y Auditoría, 2021
El mundo se encuentra ante una nueva etapa de la economía sustentada en grandes infraestructuras globales. Esta infraestructura está compuesta por bienes de capital con componentes virtuales y físicos que deben poder ser entendidos desde el marco ...
Juan Francisco Rodríguez Brites
doaj  

Inventory and quality control of biosample collection from pregnant women at different gestational ages to search for early biomarkers of pregnancy complications

Кардиоваскулярная терапия и профилактика, 2023
Aim. To conduct an inventory and quality control of biosample collection from pregnant women at different gestational ages to search for early biomarkers of pregnancy complications.Material and methods.
A. R. Maltseva, R. A. Illarionov, E. S. Vashukova, O. V. Pachulia, T. B. Postnikova, M. E. Velizhanina, A. A. Rubel, Yu. A. Nasykhova, O. N. Bespalova, A. S. Glotov   +9 more
doaj   +1 more source

Bioresource collection of blood components from pregnant women to identify fetal genetic features, as well as to search for genetic markers of gestational complications

Кардиоваскулярная терапия и профилактика, 2023
Aim. To create collection of plasma and leukocyte blood samples from pregnant women to improve methods of non-invasive prenatal testing, as well as to search for deoxyribonucleic acid markers and study the molecular mechanisms of gestational ...
E. S. Vashukova, O. A. Tarasenko, O. E. Talantova, P. Yu. Kozyulina, A. V. Morshneva, А. R. Maltseva, O. V. Pachulia, O. N. Bespalova, I. Yu. Kogan, A. S. Glotov   +9 more
doaj   +1 more source

Phenotypic Profile of Peripheral Blood NK Cells under Culturing with Trophoblast Cells and IL-15 and IL-18 Cytokines

Медицинская иммунология, 2021
Natural killer cells (NK cells) are innate immunity lymphocytes. NK cell differentiation is controlled by the cellular microenvironment and locally produced cytokines, including IL-2, IL-15 and IL-18.
V. A. Mikhailova, P. V. Grebenkina, E. V. Tyshchuk, A. A. Davydova, V. A. Zagaynova, I. Yu. Kogan, S. A. Selkov, D. I. Sokolov   +7 more
doaj   +1 more source

Microvesicles produced by natural killer cells of the NK-92 cell line affect the phenotype and functions of endothelial cells of the EA.Hy926 cell line

Медицинская иммунология, 2020
Microvesicles (MVs) are small (100-1000 nm) subcellular structures produced by both motionless and activated cells that can transfer molecules to target cells, and regulate physiological and pathological processes.
K. L. Markova, V. A. Mikhailova, A. V. Korenevsky, Yu. P. Milyutina, V. V. Rodygina, E. P. Aleksandrova, A. S. Markov, O. A. Balabas, S. A. Selkov, D. I. Sokolov   +9 more
doaj   +1 more source

Phenotypic and functional characteristics of endothelial cells: the in vitro effects of protein fractions from the lysate of natural killer-derived microvesicles

Медицинская иммунология, 2022
Microvesicles are membrane-derived formations ranging in size from 100 to 1000 nm, being produced by a variety of resting and activated cells. They can transfer their cargo to target cells, regulate physiological processes, and participate in the ...
A. V. Korenevsky, M. E. Berezkina, T. N. Gert, S. A. Sinyavin, S. A. Selkov, D. I. Sokolov   +5 more
doaj   +1 more source

The role of survivin in the pathogenesis of genital endometriosis, current application possibilities (literature review) [PDF]

Гинекология, 2020
In the structure of gynecological diseases, genital endometriosis takes the third place, and its frequency tends to increase. Endometriosis occurs in 510% of women of reproductive age, in 3550% of patients with infertility and in 7080% of women with ...
Elena V. Misharina, Maria I. Yarmolinskaya, Tatiana E. Ivashchenko, Nelly Y. Andreyeva   +3 more
doaj   +1 more source