Results 191 to 200 of about 18,941 (209)

Ouabain—The Key to Cardioprotection?

American Journal of Therapeutics, 2014
Based on a wealth of mechanistic evidence supported by the fact that ouabain mimics the spleen-liver effect in this article, the hypothesis is established that the endogenous hormone ouabain not only mimics the effects of ischemic preconditioning but also may be an ideal drug for the prevention of ischemic diseases.
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Erythrocyte sodium pump stimulation by ouabain and an endogenous ouabain‐like factor

Cell Biochemistry and Function, 2006
AbstractCardiac glycosides inhibit the sodium pump. However, some studies suggest that nanomolar ouabain concentrations can stimulate the activity of the sodium pump.In this study, using the Na+/K+‐ATPase of human erythrocytes, we compared the effect of digoxin, ouabain and an ouabain like‐factor (OLF), on 86Rb uptake.Ouabain concentrations below 10−9 ...
Balzan S, D'Urso G, Nicolini G, Forini F, Pellegrino M, Montali U   +5 more
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Erythrocyte Ouabain Binding in Dementia

Gerontology, 1983
Age-matched patients attending a geriatric psychiatry day hospital, one group with Alzheimer's dementia and another with functional illness, were studied and compared with similar inpatient groups. Erythrocyte ouabain binding was assayed and Clifton ratings completed.
Anne M. McHarg, Graham J. Naylor, Brian R. Ballinger   +2 more
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Ouabain Antagonists as Antihypertensive Agents

Current Pharmaceutical Design, 2005
The evidence that high levels of endogenous ouabain (EO), a closely related isomer of ouabain, are implicated in human hypertension and cardiac hypertrophy and failure stimulated the pharmacological research for developing novel anti-hypertensive agents active as ouabain antagonists.
P. Barassi, Mara Ferrandi, Isabella Molinari, E. Minotti, Lucia Torielli, Bianchi Giuseppe, G. Tripodi, Patrizia Ferrari   +7 more
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Modulation of the Immune System by Ouabain

Annals of the New York Academy of Sciences, 2009
Ouabain, a known inhibitor of the Na,K‐ATPase, has been shown to regulate a number of lymphocyte functions in vitro and in vivo. Lymphocyte proliferation, apoptosis, cytokine production, and monocyte function are all affected by ouabain. The ouabain‐binding site occurs at the α subunit of the enzyme. The α subunit plays a critical role in the transport
Ottilia R. Affonso-Mitidieri, Andreia Da Silva de Oliveira, Franklin David Rumjanek, Vivian M. Rumjanek, Sandra Rodrigues-Mascarenhas, Nivea Dias Amoedo   +5 more
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Relationship between ouabain and asthenozoospermia

Journal of Huazhong University of Science and Technology [Medical Sciences], 2014
A growing number of researches have shown that ouabain can regulate mammalian sperm function and male reproduction by modulating the sperm motility, capacitation and acrosome reaction in vitro. This study further examined the relationship between ouabain and asthenozoospermia.
Ting Xue, Yi-hong Yang, Huan Lou, Yan Wan, Ping Su   +4 more
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Ouabain on the hypothermic dog heart

American Heart Journal, 1958
Abstract The effect of digitalization with ouabain on the susceptibility of the hypothermic heart to ventricular fibrillation (VF) was tested in dogs. Spontaneous VF did not occur with greater frequency in digitalized animals than in controls. Similarly, ouabain did not alter significantly the incidence of VF during experimental ventriculotomy under ...
J. Torres, E.T. Angelakos, R. Driscoll
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Ouabain Hypoglycemia: Insulin Mediation

Science, 1968
The fall in blood sugar occurring during infusion of ouabain (1 microgram per kilogram per minute for a 60-minute period) in dogs is accompanied by an increased uptake of glucose and potassium by the liver. Concurrently, plasma insulin in the portal blood increases significantly.
L. Triner, Gabriel G. Nahas, Paul Killian   +2 more
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FISH OSMOREGULATE WITH OUABAIN

Journal of Experimental Biology, 2005
![Figure][1] OSMOREGULATION Ouabain, a potent inhibitor of the enzyme Na+/K+-ATPase, is known to be a steroid hormone in mammals that is involved in blood pressure and volume regulation.
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Apical ouabain-sensitive and ouabain-insensitive ATPases in rat colonic epithelium

Acta Histochemica, 2002
Active resorption of potassium ions in the colon is mediated by ouabain-sensitive and ouabain-insensitive H,K-ATPases localized in the apical membrane of colonic enterocytes (colonocytes). The present study was performed to investigate distribution patterns of apical ATPases using catalytic histochemistry and immunohistochemistry.
Radomíra Vagnerová, Zdeňka Zemanová, Jiří Pácha, Jaroslava Šmídová   +3 more
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