Results 171 to 180 of about 22,704 (219)
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Cell Calcium, 2020
In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca2+ concentration ([Ca2+]CYT) via Na/Ca exchange (NCX), and ii) in activating a number of protein kinase (PK) signaling cascades that control a myriad of cell functions. Importantly,
Mordecai P. Blaustein, John M. Hamlyn
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In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca2+ concentration ([Ca2+]CYT) via Na/Ca exchange (NCX), and ii) in activating a number of protein kinase (PK) signaling cascades that control a myriad of cell functions. Importantly,
Mordecai P. Blaustein, John M. Hamlyn
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Ouabain-Stimulated Trafficking Regulation of the Na/K-ATPase and NHE3 in Renal Proximal Tubule Cells
Molecular and Cellular Biochemistry, 2012 We have demonstrated that ouabain regulates protein trafficking of the Na/K-ATPase a1 subunit and NHE3 (Na/H exchanger, isoform 3) via ouabain-activated Na/K-ATPase signaling in porcine LLC-PK1 cells.
Joseph I Shapiro, Xie Zie, Yanling Yan
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Ouabain as a Mammalian Hormone
Annals of the New York Academy of Sciences, 2003Abstract: Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the μ chain of IgM ...
Wilhelm, Schoner +12 more
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Current Opinion in Nephrology and Hypertension, 1998
Accumulated evidence has suggested that several sodium pump inhibitors, similar to cardiotonic steroids, are present in the human body. Ouabain-like factor, the most appealing candidate, has been found to be increased with high sodium intake and hypervolaemia, and in essential hypertension, mineralocorticoid hypertension, and pregnancy-induced ...
A, Goto, K, Yamada
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Accumulated evidence has suggested that several sodium pump inhibitors, similar to cardiotonic steroids, are present in the human body. Ouabain-like factor, the most appealing candidate, has been found to be increased with high sodium intake and hypervolaemia, and in essential hypertension, mineralocorticoid hypertension, and pregnancy-induced ...
A, Goto, K, Yamada
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Mechanisms of ouabain toxicity
The FASEB Journal, 2003ABSTRACT The suggested involvement of ouabain in hypertension raised the need for a better understanding of its cellular action, but the mechanisms of ouabain toxicity are only now being uncovered. In the present study, we show that reduced glutathione (GSH) protected ouabain‐sensitive (OS) cells from ouabain ...
Raphael C, Valente +5 more
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Virology, 1978
Abstract The effects of ouabain on Sindbis virus replication in cloned sublines of ouabain-sensitive (B 1 C 4 ) and -resistant (Oua 5 ) Aedes albopictus cells have been studied. The addition of ouabain (0.1 m M ) to B 1 C 4 cells 1 hr after infection reduced the yield of infectious virus 500-fold.
S J, Mento, V, Stollar
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Abstract The effects of ouabain on Sindbis virus replication in cloned sublines of ouabain-sensitive (B 1 C 4 ) and -resistant (Oua 5 ) Aedes albopictus cells have been studied. The addition of ouabain (0.1 m M ) to B 1 C 4 cells 1 hr after infection reduced the yield of infectious virus 500-fold.
S J, Mento, V, Stollar
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Role of Ouabain-Like Factors in Hypertension
Journal of Cardiovascular Pharmacology, 1993Several reports suggest the presence of sodium-potassium pump inhibitor in plasma and various tissues, particularly during volume-expanded state and low-renin hypertension. It has been hypothesized that by inhibiting the cardiovascular muscle-cell Na(+)-K+ pump, this inhibitor can constrict blood vessels, enhance vasoconstriction, and increase cardiac ...
YUAN C +5 more
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Endogenous Ouabain in Ménière's Disease
Otology & Neurotology, 2010Endogenous Ouabain (EO) has been demonstrated to modulate the activity of Na+, K+ -ATPase. Our purpose was to measure plasma levels of EO in Ménière's Disease (MD) subjects as a possible predisposing factor to developing and maintaining hydrops.Case-control study.University hospital.Thirty-nine MD subjects and 29 controls with a lifetime negative ...
Teggi Roberto +7 more
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Ouabain—The Key to Cardioprotection?
American Journal of Therapeutics, 2014Based on a wealth of mechanistic evidence supported by the fact that ouabain mimics the spleen-liver effect in this article, the hypothesis is established that the endogenous hormone ouabain not only mimics the effects of ischemic preconditioning but also may be an ideal drug for the prevention of ischemic diseases.
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Apical ouabain-sensitive and ouabain-insensitive ATPases in rat colonic epithelium
Acta Histochemica, 2002Active resorption of potassium ions in the colon is mediated by ouabain-sensitive and ouabain-insensitive H,K-ATPases localized in the apical membrane of colonic enterocytes (colonocytes). The present study was performed to investigate distribution patterns of apical ATPases using catalytic histochemistry and immunohistochemistry.
Radomíra, Vagnerová +3 more
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