Results 91 to 100 of about 170,036,221 (278)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Under-triage in telephone consultation is related to non-normative symptom description and interpersonal communication: a mixed methods study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2017
Background Telephone consultation and triage are used to limit the workload on emergency departments. Lack of visual cues and clinical tests put telephone consultations to a disadvantage compared to face-to-face consultations increasing the risk of under-
Hejdi Gamst-Jensen, Freddy K. Lippert, Ingrid Egerod   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

General practitioners' satisfaction with and attitudes to out-of-hours services

BMC Health Services Research, 2005
Background In recent years, Dutch general practitioner (GP) out-of-hours service has been reorganised into large-scale GP cooperatives. Until now little is known about GPs' experiences with working at these cooperatives for out-of-hours care. The purpose
Wesseling Geertjan, Voss Gemma BWE, Nieman Fred HM, van Uden Caro JT, Winkens Ron AG, Crebolder Harry FJM   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

General practitioners' perceptions of after hours primary medical care services: a Toowoomba, Queensland, Australia study [PDF]

, 2004
[Abstract]: This article reports on a project, undertaken in 2002 in the regional city of Toowoomba, Queensland, Australia, that investigated the viability of establishing an after-hours primary medical care (AHPMC) service.
Nanka, Annette, Hegney, Desley, Fahey, Paul P.   +2 more
core   +1 more source

Variations in patient safety climate and perceived quality of collaboration between professions in out-of-hours care

Journal of Multidisciplinary Healthcare, 2017
Zalika Klemenc-Ketis,1–3 Ellen Tveter Deilkås,4 Dag Hofoss,5 Gunnar Tschudi Bondevik6,7 1Department of Family Medicine, Faculty of Medicine, University of Maribor, Maribor, 2Department of Family Medicine, Faculty of Medicine, University of ...
Klemenc-Ketis Z, Deilkås ET, Hofoss D, Bondevik GT   +3 more
doaj  

The effectiveness of Nurse Practitioners working at a GP cooperative: a study protocol

BMC Family Practice, 2012
Background In many countries out-of-hours care faces serious challenges, including shortage of general practitioners, a high workload, reduced motivation to work out of hours, and increased demand for out-of-hours care.
Wijers Nancy, Schoonhoven Lisette, Giesen Paul, Vrijhoef Hubertus, van der Burgt Regi, Mintjes Joke, Wensing Michel, Laurant Miranda   +7 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Patient safety culture in Slovenian out-of-hours primary care clinics

Slovenian Journal of Public Health, 2017
Patient safety culture is a concept which describes how leader and staff interaction, attitudes, routines and practices protect patients from adverse events in healthcare.
Klemenc-Ketiš Zalika, Deilkås Ellen Tveter, Hofoss Dag, Bondevik Gunnar Tschudi   +3 more
doaj   +1 more source