Results 101 to 110 of about 170,036,221 (278)

Health system changes needed to support people consulting general practice out of hours services in Ireland

International Journal of Mental Health Systems, 2018
Background Mental illness acts as a barrier to accessing and obtaining effective medical care. It has been shown that out of hours services are an important first stop for emergency care for people experiencing mental health difficulties. However, little
C. Collins, M. T. O’Shea, J. Cunniffe, P. Finegan   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Point-of-care testing and antibiotics prescribing in out-of-hours general practice: a register-based study in Denmark

BMC Primary Care
Background Point-of-care testing may reduce diagnostic uncertainty in case of suspicion of bacterial infection, thereby contributing to prudent antibiotic prescribing.
Line Due Christensen, Claus Høstrup Vestergaard, Ellen Keizer, Bodil Hammer Bech, Flemming Bro, Morten Bondo Christensen, Linda Huibers   +6 more
doaj   +1 more source

End-of-life hospital referrals by out-of-hours general practitioners: a retrospective chart study

BMC Family Practice, 2012
Background Many patients are transferred from home to hospital during the final phase of life and the majority die in hospital. The aim of the study is to explore hospital referrals of palliative care patients for whom an out-of-hours general ...
De Korte-Verhoef Maria C, Pasman H Roeline W, Schweitzer Bart PM, Francke Anneke L, Onwuteaka-Philipsen Bregje D, Deliens Luc   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Survey of health care student attitudes towards transgender health care education

Translation, 2018
Background: This study assessed health care trainees perceptions of their education regarding transgender health care issues and personal and professional comfort level with the provision of transgender health care.
Vipul Shukla, Alex Asp, Barbara Saltzman, Joan Duggan   +3 more
doaj   +1 more source

[Advance Directives and Palliative Medical Care in Nursing Homes: A Study on Everyday Life and Relevance in Out-of-Hours Medical Care]. [PDF]

Gesundheitswesen, 2023
Witthauer B, Kolominsky-Rabas P.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Nurse telephone triage in out of hours primary care: a pilot study

, 1997
The “crisis” in out of hours primary care 1 2 and availability of new development funding 3 have prompted new service arrangements, primarily general practice cooperatives and primary care emergency centres.
South Wiltshire Out of Hours Project (SWOOP) Group, Moore, M.   +1 more
core   +1 more source