Results 81 to 90 of about 170,036,221 (278)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

MOESM2 of Contacting out-of-hours primary care or emergency medical services for time-critical conditions - impact on patient outcomes

, 2019
Additional file 2. Adjusted analysis of the association between OOH service, ICU stay and mortality (N = 6826). Analysis of the association between OOH service, 1- and 1–30-day mortality and ICU stay. Adjusted for age, gender, ethnicity, employment status, education level, income level & comorbidity. * NR = not reported due to too few observations.
Søvsø, Morten, Christensen, Morten, Bech, Bodil, Christensen, Helle, Christensen, Erika, Huibers, Linda   +5 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

MOESM3 of Contacting out-of-hours primary care or emergency medical services for time-critical conditions - impact on patient outcomes

, 2019
Additional file 3. Sensitivity analysis for the association between OOH service, ICU stay and mortality (N = 6826). Crude analysis of the association between OOH service, 1- and 1–30 day mortality and ICU stay using the patients’ last hospital contact during the study period.
Søvsø, Morten, Christensen, Morten, Bech, Bodil, Christensen, Helle, Christensen, Erika, Huibers, Linda   +5 more
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Rural GPs’ attitudes toward participating in emergency medicine: a qualitative study

Scandinavian Journal of Primary Health Care, 2016
Objective: Health authorities want to increase general practitioner (GP) participation in emergency medicine, but the role of the GP in this context controversial. We explored GPs’ attitudes toward emergency medicine and call outs.
Magnus Hjortdahl, Peder Halvorsen, Mette Bech Risør   +2 more
doaj   +1 more source

MOESM1 of Contacting out-of-hours primary care or emergency medical services for time-critical conditions - impact on patient outcomes

, 2019
Additional file 1. ICD-10 codes included in study population. List of all included ICD-10 codes in the study.
Søvsø, Morten, Christensen, Morten, Bech, Bodil, Christensen, Helle, Christensen, Erika, Huibers, Linda   +5 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Factors related to out-of-hours help-seeking for acute health problems: a survey study using case scenarios

BMC Public Health, 2019
Background The acute out-of-hours healthcare services are challenged by increasing demand in many countries. We aimed to examine factors influencing the intended help-seeking in out-of-hours care for acute health problems during evenings, nights, and ...
Ellen Keizer, Morten Bondo Christensen, Anders Helles Carlsen, Marleen Smits, Michel Wensing, Oliver Senn, Linda Huibers   +6 more
doaj   +1 more source