Results 41 to 50 of about 473,213 (294)
Advanced Science, EarlyView.The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang +9 more
wiley +1 more source
NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
Advanced Science, EarlyView.Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong +18 more
wiley +1 more source
International Journal of Infectious Diseases, 2023 Intro: Understanding sex-related differences and gendered roles in outbreak dynamics is critical to deliver an effective response. Despite existing recommendations and minimum requirements, collection, analysis, and use of sex-disaggregated data and ...
M. Gales +9 more
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A case of human survival of rabies, South Africa
Southern African Journal of Infectious Diseases, 2016 Human survival from rabies is exceptionally rare. We report a case of human survival (with severe neurological sequelae) in a child from South Africa.
Jacqueline Weyer +8 more
doaj +1 more source
Advanced Science, EarlyView.The continental‐scale study reveals that soil phosphorus strongly predicts the richness of soil pathogenic oomycetes in Chinese grasslands, while precipitation and plant species richness drive their absolute abundance; modeling predicts ≈42% of grassland areas may face elevated oomycete disease risk under future climate scenarios, especially in typical
Junsheng Ke +10 more
wiley +1 more source
Advanced Science, EarlyView.This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado +10 more
wiley +1 more source
Advanced Science, EarlyView.Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil +12 more
wiley +1 more source
A simple approach to measure transmissibility and forecast incidence
Epidemics, 2018 Outbreaks of novel pathogens such as SARS, pandemic influenza and Ebola require substantial investments in reactive interventions, with consequent implementation plans sometimes revised on a weekly basis.
Pierre Nouvellet +13 more
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