Results 41 to 50 of about 1,200,960 (324)

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

The impact of stratified immunity on the transmission dynamics of influenza

Epidemics, 2017
Although empirical studies show that protection against influenza infection in humans is closely related to antibody titres, influenza epidemics are often described under the assumption that individuals are either susceptible or not.
Hsiang-Yu Yuan, Marc Baguelin, Kin O. Kwok, Nimalan Arinaminpathy, Edwin van Leeuwen, Steven Riley   +5 more
doaj   +1 more source

Enterohemorrhagic Escherichia coli with particular attention to the German outbreak strain O104:H4 [PDF]

, 2012
This review deals with the epidemiology and ecology of enterohemorrhagic Escherichia coli (EHEC), a subset of the verocytotoxigenic Escherichia coli (VTEC), and subsequently discusses its public health concern.
De Reu, K, De Zutter, Lieven, Joris, Adelheid, Vanrompay, Daisy, Verstraete, K   +4 more
core   +1 more source

Size of Outbreaks Near the Epidemic Threshold

, 2004
The spread of infectious diseases near the epidemic threshold is investigated. Scaling laws for the size and the duration of outbreaks originating from a single infected individual in a large susceptible population are obtained.
C. Lefevre, D. Stauffer, E. Ben-Naim, F. Ball, H. Andersson, H. E. Daniels, H. W. Hethcote, J. Bull, J. D. Murray, N. G. Van Kampen, N. T. J. Bailey, P. L. Krapivsky, R. Anderson, T. E. Harris   +13 more
core   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Identification and Expression Analysis of the Cytochrome P450 Genes in Phyllotreta striolata and CYP6TH1/CYP6TH2 in the Involvement of Pyridaben Tolerance

Insects
The striped flea beetle, Phyllotreta striolata, is a worldwide pest that causes severe damage to cruciferous crops. Pyridaben, an inhibitor of mitochondrial complex I, has been widely used for the control of P. striolata.
Yongqin Zhu, Zhongting Liu, Wenyong Mai, Xinhua Pu, Haoyue Mo, Benshui Shu, Zhongzhen Wu   +6 more
doaj   +1 more source

Using Electronic Health Record Data to Measure the Latent Tuberculosis Infection Care Cascade in Safety-Net Primary Care Clinics

AJPM Focus, 2023
Introduction: Prevention of tuberculosis disease through diagnosis and treatment of latent tuberculosis infection is critical for achieving tuberculosis elimination in the U.S.
Laura A. Vonnahme, MPH, Julia Raykin, PhD, Matthew Jones, MS, Jee Oakley, MPH, Jon Puro, MPA, Adam Langer, DVM, Kaylynn Aiona, MPH, Robert Belknap, MD, Tracy Ayers, PhD, Jonathan Todd, PhD, Kathryn Winglee, PhD   +10 more
doaj   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Outbreak of autochthonous West Nile virus infection in Lazio region, Italy, July to August 2025: preliminary investigation

Eurosurveillance
In July–18 August 2025, 171 autochthonous cases with West Nile virus (WNV) infection were confirmed in Lazio, Italy: four asymptomatic blood donors, 110 with WNV fever, 57 with neuroinvasive syndrome and nine deaths.
the Lazio WNV Outbreak Group
doaj   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source