Results 11 to 20 of about 32,094 (189)

Comparison of Gut Microbiological Profiles of Inbred and Outbred Healthy Mice [PDF]

MicrobiologyOpen
Gut microbes are closely related to host immunity and health, and mice are frequently used as a common model organism in biomedicine to study various diseases.
Xudong Liu, Shitao Lian, Aoyi Xiao, Xiafei Hong, Dingyan Cao, Xinjie Xu, Yanan Shi, Qing Zhong, Hangqi Liu, Wenjing Wang, Jinyuan Wang, Zilong He, Wenming Wu   +12 more
doaj   +2 more sources

Genotyping by genome reducing and sequencing for outbred animals. [PDF]

PLoS ONE, 2013
Next-generation sequencing (NGS) approaches are widely used in genome-wide genetic marker discovery and genotyping. However, current NGS approaches are not easy to apply to general outbred populations (human and some major farm animals) for SNP ...
Qiang Chen, Yufang Ma, Yumei Yang, Zhenliang Chen, Rongrong Liao, Xiaoxian Xie, Zhen Wang, Pengfei He, Yingying Tu, Xiangzhe Zhang, Changsuo Yang, Hongjie Yang, Fuqing Yu, Youmin Zheng, Zhiwu Zhang, Qishan Wang, Yuchun Pan   +16 more
doaj   +5 more sources

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice

Frontiers in Immunology, 2017
Recent work has suggested that current mouse models may underrepresent the complexity of human immune responses. While most mouse immunology studies utilize inbred mouse strains, it is unclear if conclusions drawn from inbred mice can be extended to all ...
Derek B Danahy, Stacey M Hartwig, John T Harty   +2 more
exaly   +3 more sources

Cleaning Genotype Data from Diversity Outbred Mice [PDF]

G3: Genes, Genomes, Genetics, 2019
Data cleaning is an important first step in most statistical analyses, including efforts to map the genetic loci that contribute to variation in quantitative traits.
Karl W. Broman, Daniel M. Gatti, Karen L. Svenson, Śaunak Sen, Gary A. Churchill   +4 more
doaj   +4 more sources

Extreme intraspecific divergence in mitochondrial haplotypes makes the threespine stickleback fish an emerging evolutionary mutant model for mito-nuclear interactions

Frontiers in Genetics, 2022
Mitochondrial DNA is primarily maternally inherited in most animals and evolves about 10 times faster than biparentally inherited nuclear DNA. Mitochondrial dysfunction (mt-dys) arises when interactions between the co-evolving mitochondrial and nuclear ...
Emily A. Beck, Emily A. Beck, Susan Bassham, William A. Cresko, William A. Cresko   +4 more
doaj   +1 more source

Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders

Frontiers in Psychiatry, 2022
Many personality traits are influenced by genetic factors. Rodents models provide an efficient system for analyzing genetic contribution to these traits.
Mustafa Hakan Gunturkun, Tengfei Wang, Apurva S. Chitre, Angel Garcia Martinez, Katie Holl, Celine St. Pierre, Hannah Bimschleger, Jianjun Gao, Riyan Cheng, Oksana Polesskaya, Leah C. Solberg Woods, Abraham A. Palmer, Abraham A. Palmer, Hao Chen   +13 more
doaj   +1 more source

Contrasting characteristic behaviours among common laboratory mouse strains [PDF]

Royal Society Open Science, 2019
Mice are widely used to model wide-ranging human neurological disorders, from development to degenerative pathophysiology. Behavioural and molecular characteristics of these mouse models are influenced by the genetic background of each strain.
Razia Sultana, Olalekan M. Ogundele, Charles C. Lee   +2 more
doaj   +1 more source

The diversity outbred mouse population [PDF]

Mammalian Genome, 2012
The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically heterogeneous DO mice display a broad range of phenotypes. Natural levels of heterozygosity provide genetic buffering and, as a result, DO mice are robust and breed well.
Churchill, Gary A, Gatti, Daniel M, Munger, Steven C, Svenson, Karen L   +3 more
openaire   +3 more sources

Inbreeding depression in an outbred stickleback population

Molecular Ecology, 2023
AbstractInbreeding depression refers to the reduced fitness of offspring produced by genetically‐related individuals and is expected to be rare in large, outbred populations. When it occurs, marked fitness loss is possible as large populations can carry a substantial load of recessive harmful mutations which are normally sheltered at the heterozygous ...
Antoine Fraimout, Pasi Rastas, Lei Lv, Juha Merilä   +3 more
openaire   +3 more sources

Small bowel transplantation in outbred rats [PDF]

Acta Cirurgica Brasileira, 2011
PURPOSE: To investigate the clinical evolution of orthotopic small bowel transplantation in outbred rats. METHODS: Seventy-two outbred Wistar rats weighting from 250 to 300g were used as donor and recipient in 36 consecutives ortothopic small intestine transplantation without immunosuppression. The graft was transplanted into the recipient using end-to-
Waisberg, Daniel Reis, Lee, André Dong Wong, Santos, Rafael Miyashiro Nunes dos, Mory, Eduardo Kenji, Costa, Anderson Lino, Montero, Edna Frasson de Souza, Chaib, Eleazar, D'Albuquerque, Luis Augusto Carneiro, Galvao, Flavio Henrique Ferreira   +8 more
openaire   +4 more sources