Results 41 to 50 of about 32,094 (189)
Combined detection and introgression of QTL in outbred populations [PDF]
Genetics Selection Evolution, 2010 Detecting a QTL is only the first step in genetic improvement programs. When a QTL with desirable characteristics is found, e.g. in a wild or unimproved population, it may be interesting to introgress the detected QTL into the commercial population.
Yazdi, M.H. +3 more
openaire +4 more sources
International Standardized Nomenclature for Outbred Stocks of Laboratory Animals
ILAR Journal, 2021 Preface by the Secretary-General of ICLA In accordance with the «Aims of ICLA» (ICLA Bulletin No. 26, March 1970) the Governing Board established in 1969 a Working Party to prepare an International Nomenclature System for Outbred Animals. The members were: Professor, Dr. A. Spiegel, Federal Republic of Germany, chairman.Dr.
M, Festing +4 more
openaire +3 more sources
Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.
PLoS ONE, 2018 Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and the tools to assess these vaccines.
Raju Sunagar +5 more
doaj +1 more source
Frontiers in Genetics, 2021 Prior work in late-onset Alzheimer’s disease (LOAD) has resulted in discrepant findings as to whether recent consanguinity and outbred autozygosity are associated with LOAD risk.
Valerio Napolioni +4 more
doaj +1 more source
Acta Neuropathologica Communications, 2022 The long-lived Chilean rodent (Octodon degus) has been reported to show spontaneous age-dependent neuropathology and cognitive impairments similar to those observed in human AD.
Zhiqun Tan +7 more
doaj +1 more source
Induction of liver transplant immune tolerance in an outbred rat strain model using tacrolimus
Laboratory Animal Research, 2023 Background Orthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant immunosuppressive therapy is important to prevent graft failure.
Min-Jung Park +9 more
doaj +1 more source
Viruses, 2022 African swine fever virus is currently present in all of the world’s continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine.
Lynnette C. Goatley +7 more
doaj +1 more source
High-resolution mapping of gene expression using association in an outbred mouse stock.
PLoS Genetics, 2008 Quantitative trait locus (QTL) analysis is a powerful tool for mapping genes for complex traits in mice, but its utility is limited by poor resolution. A promising mapping approach is association analysis in outbred stocks or different inbred strains. As
Anatole Ghazalpour +10 more
doaj +1 more source
Genetic variation and population substructure in outbred CD-1 mice: implications for genome-wide association studies. [PDF]
PLoS ONE, 2009 Outbred laboratory mouse populations are widely used in biomedical research. Since little is known about the degree of genetic variation present in these populations, they are not widely used for genetic studies.
Kimberly A Aldinger +4 more
doaj +1 more source
STAR Protocols, 2022 Summary: Identifying germline differentially methylated regions (DMRs) in outbred mammals remains a challenge because of difficulty in obtaining single-nucleotide polymorphisms (SNPs).
Wenhao Zhang, Yi Zhang
doaj +1 more source