Results 61 to 70 of about 32,094 (189)
Demographic costs of inbreeding revealed by sex-specific genetic rescue effects
BMC Evolutionary Biology, 2009 Background Inbreeding can slow population growth and elevate extinction risk. A small number of unrelated immigrants to an inbred population can substantially reduce inbreeding and improve fitness, but little attention has been paid to the sex-specific ...
Zajitschek Felix +2 more
doaj +1 more source
Polymorphism and differential expression of MHC classⅠgenes between different strains of guinea pig
浙江大学学报. 农业与生命科学版, 2021 Guinea pig is a laboratory animal model to study the illness and stimulation of infection. The previous studies showed that the sensitivity of Zmu-1∶DHP outbred guinea pig to foot-and-mouth disease virus was 100%, which was significantly different from ...
WEI Zhen +3 more
doaj +1 more source
Zebrafish inversin mutants develop scoliosis in the absence of laterality defects
Developmental Dynamics, EarlyView.Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick +3 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
qtl.outbred: Interfacing outbred line cross data with the R/qtl mapping software
BMC Research Notes, 2011 Background qtl.outbred is an extendible interface in the statistical environment, R, for combining quantitative trait loci (QTL) mapping tools. It is built as an umbrella package that enables outbred genotype probabilities to be calculated and/or ...
Carlborg Örjan +2 more
doaj +1 more source
An experimental study: Does inbreeding increase the motivation to mate? [PDF]
PLoS ONE, 2018 Inbreeding is a central topic in evolutionary biology and ecology and is of major concern for the conservation of endangered species. Yet, it remains challenging to comprehend the fitness consequences of inbreeding, because studies typically focus only ...
Raïssa A de Boer +2 more
doaj +1 more source
Protamines in the sperm heads of inbred and outbred mice [PDF]
Reproduction, 1977 The spermatozoa of inbred mice have been of interest since the discogery of unusual variations in sperm shape in different straings (Braden, 1959). The shape variation led in turn to the discovery of an unusual segregation of transplantation genes in the progeny of these mice when mated to other inbred strains.
openaire +2 more sources
Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction
ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner +10 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley +11 more
wiley +1 more source
Inbreeding in Mimulus guttatus reduces visitation by bumble bee pollinators. [PDF]
PLoS ONE, 2014 Inbreeding in plants typically reduces individual fitness but may also alter ecological interactions. This study examined the effect of inbreeding in the mixed-mating annual Mimulus guttatus on visitation by pollinators (Bombus impatiens) in greenhouse ...
David E Carr +2 more
doaj +1 more source