Results 71 to 80 of about 32,094 (189)

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

open access: yesPhytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan   +2 more
wiley   +1 more source

Growth of human breast cancers in Peromyscus

open access: yesDisease Models & Mechanisms, 2018
Modeling breast cancer in general and hormone-sensitive breast cancer, in particular in mice, has several limitations. These are related to the inbred nature of laboratory mice, and do not allow adequate appreciation of the contribution of the host's ...
Vimala Kaza   +5 more
doaj   +1 more source

Plasticity in parental care: Interspecific competitor cues shape biparental cooperation in a burying beetle

open access: yesJournal of Animal Ecology, EarlyView.
Our study contributes to our understanding of the effects of interspecific competition in species with biparental care where male and female parents must somehow coordinate their response to interspecific competition. Abstract Interspecific competition is an important evolutionary driver of many species' life histories and behaviours, arising wherever ...
Casey Patmore, Per T. Smiseth
wiley   +1 more source

Comparison of commonly used ICR stocks and the characterization of Korl:ICR

open access: yesLaboratory Animal Research, 2017
Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infection and pharmacology research.
Hye-Jun Shin   +7 more
doaj   +1 more source

Ecological and social factors lead to variation in parental care between sexes in a burying beetle

open access: yesInsect Science, EarlyView.
We experimentally investigated the effects of ecological (resource availability and interspecific competition) and social factors (intraspecific competition) on parental care and reproductive success in the burying beetle Nicrophorus vespilloides. Our results showed that males and females adjust their parental care based on resource availability and ...
Donghui Ma, Long Ma, Jan Komdeur
wiley   +1 more source

Creating outbred and inbred populations in haplodiploids to measure adaptive responses in the laboratory

open access: yesEcology and Evolution, 2020
Laboratory studies are often criticized for not being representative of processes occurring in natural populations. One reason for this is the fact that laboratory populations generally do not capture enough of the genetic variation of natural ...
Diogo P. Godinho   +8 more
doaj   +1 more source

Volumetric Comparison of Overall Brain and Neuropil Size Between Social and Non‐social Spiders: Exploring the Social Brain Hypothesis

open access: yesIntegrative Zoology, EarlyView.
Brain size may be influenced by the cognitive demands of sociality (social brain hypothesis). We used microCT to compare CNS and brain volumes in social versus solitary huntsman and crab spiders. Social huntsman spiders had larger arcuate and mushroom bodies, while social crab spiders had larger visual neuropils.
Vanessa Penna‐Gonçalves   +6 more
wiley   +1 more source

A loss of heterozygosity, a loss in competition? The effects of inbreeding, pre‐ and postnatal conditions on nestling development

open access: yesEcology and Evolution, 2016
The early developmental trajectory is affected by genetic and environmental factors that co‐depend and interact often in a complex way. In order to distinguish their respective roles, we used canaries (Serinus canaria) of different genetic backgrounds ...
Raïssa A. deBoer   +2 more
doaj   +1 more source

Dual Beneficial Effects of Topical l‐Glutamine on Oral Mucositis in 5‐Fluorouracil‐Treated Mice

open access: yesJournal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Oral mucositis is a severe health and economic problem that occurs in about 40%–90% of patients undergoing cancer treatments. Systemic or topical application of l‐glutamine has been shown to improve mucosal healing and ameliorate oral mucositis (OM) symptoms according to clinical score systems.
Juliana Francisca Grossi Heleno   +7 more
wiley   +1 more source

The genetic architecture of leaf vein density and its importance for photosynthesis in maize

open access: yesNew Phytologist, EarlyView.
Vein types in maize leaves. Summary Leaf venation density has significantly increased during plant evolution. Higher densities are observed in angiosperms compared with early land plants, and among angiosperms, recently diverged C4 species have the highest values.
José Luis Coyac‐Rodríguez   +9 more
wiley   +1 more source

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