Results 51 to 60 of about 32,094 (189)

Intramembranous Bone Regeneration in Diversity Outbred Mice is Heritable

SSRN Electronic Journal, 2022
There are over one million cases of failed bone repair in the U.S. annually, resulting in substantial patient morbidity and societal costs. Multiple candidate genes affecting bone traits such as bone mineral density have been identified in human subjects and animal models using genome-wide association studies (GWAS). This approach for understanding the
Meghan M, Moran, Frank C, Ko, Larry D, Mesner, Gina M, Calabrese, Basel M, Al-Barghouthi, Charles R, Farber, D Rick, Sumner   +6 more
openaire   +2 more sources

QTL Mapping in Outbred Tetraploid (and Diploid) Diallel Populations [PDF]

Genetics, 2020
ABSTRACT Over the last decade, multiparental populations have become a mainstay of genetics research in diploid species. Our goal was to extend this paradigm to autotetraploids by developing software for quantitative trait locus (QTL) mapping in connected F1 populations derived from a set of shared parents. For QTL discovery, phenotypes
Rodrigo R Amadeu, Patricio R Muñoz, Chaozhi Zheng, Jeffrey B Endelman   +3 more
openaire   +2 more sources

Evolution of haplodiploidy: Models for inbred and outbred systems [PDF]

Theoretical Population Biology, 1980
Several new models are proposed for the evolution of haplodiploidy. Each of these models is evaluated for its ability to explain (1) special problems associated with transition to haplodiploidy from a population of diplodiploid progenitors, (2) current patterns of population structure in haplodiploid and related species, and (3) the evolution of ...
openaire   +3 more sources

Interactions between maternal provisioning and natural selection on seed mass fluctuate across heat waves

American Journal of Botany, EarlyView.
Abstract Premise Changing climates are leading to more frequent and severe heat waves, potentially threatening plant populations. Both acclimation to stress and selection for heat‐escape or heat‐resistance phenotypes occur during heat waves. However, plastic responses and selection do not necessarily interact cohesively—even producing trait responses ...
Lana F. Gaspard, Elissa Harb, Stacy D. Holt Jr., Courtney M. Patterson, Nicholas J. Kooyers   +4 more
wiley   +1 more source

The Resistance to Traction Forces Differs Substantially Between Intestinal Parts, but Not Between In- and Outbred Strains of Mice

Gastroenterology Insights
Background/Objectives: Anastomoses under tension are associated with anastomotic leaks and strictures. In experimental surgery, anastomoses are frequently tested for their resistance to traction forces, but without the surgically untouched organ as a ...
Berkan Ertim, Ejder Akinci, Maximiliane von Stumberg, David Katzer, Rainer Ganschow, Tim O. Vilz, Christina Oetzmann von Sochaczewski   +6 more
doaj   +1 more source

Born this way: Does variation in perinatal limb bone morphology predict adult locomotor repertoire in primates?

The Anatomical Record, EarlyView.
Abstract Primates show a high degree of locomotor diversity that engenders similar variance in limb bone cross‐sectional geometry and bending strength: leaping primates have stronger hindlimb bones whereas suspensory species have stronger forelimb bones.
Angela M. Mossor, Jeremy Busken, Lorna Benden, Ethan Mardovin, Andrew Bostick, Grégoire Boulinguez‐Ambroise, Timothy D. Smith, Jesse W. Young   +7 more
wiley   +1 more source

Improving precision and accuracy of genetic mapping with genotyping‐by‐sequencing data in outcrossing species

GCB Bioenergy
Genotyping‐by‐sequencing (GBS) is a widely used strategy for obtaining large numbers of genetic markers in model and non‐model organisms. In crop plants, GBS‐derived marker datasets are frequently used to perform quantitative trait locus (QTL) mapping ...
Nicholas R. LaBonte, Dessireé P. Zerpa‐Catanho, Siyao Liu, Liang Xiao, Hongxu Dong, Lindsay V. Clark, Erik J. Sacks   +6 more
doaj   +1 more source

Comparative pharmacokinetics of porcine and human anti-influenza hemagglutinin monoclonal antibodies in outbred pigs and minipigs

Frontiers in Immunology
Assessing the pharmacokinetics of monoclonal antibodies (mAbs) in relevant animal models is essential for designing improved formulations and developing mAb delivery platforms.
Basudev Paudyal, Elliot Moorhouse, Bhawna Sharma, Michael Dodds, Victor Nguyen, Mark Milad, Elma Tchilian   +6 more
doaj   +1 more source

The genetic component of the forced diving bradycardia response in mammals

Frontiers in Physiology, 2011
We contrasted the forced diving bradycardia between two genetically similar (inbred) rat strains (Fischer and Buffalo), compared to that of outbred rats (Wistar). The animals were habituated to forced diving for 4 weeks.
Andreas eFahlman, Brian L Bostrom, Kiran H Dillon, David R Jones   +3 more
doaj   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source