Results 101 to 110 of about 549,867 (276)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement [PDF]

, 2008
Peer ...
Deverill, M, L Vale, Pickard, R., N'Dow, J, Vale, L., Fraser, C., Armstrong, N, T Lourenco, M Deverill, S Wong, Lourenco, T, McClinton, S, N'Dow, J., Grant, A, Mowatt, G., Grant, A., C Fraser, Coutts, A., J N'Dow, Mowatt, G, G Nabi, Fraser, C, N Armstrong, Pickard, R, G MacLennan, S McClinton, Armstrong, N., Vale, L, Wong, S, Coutts, A, MacLennan, G, Wong, S., A Grant, R Pickard, A Coutts, Lourenco, T., Deverill, M., G Mowatt, Nabi, G, Nabi, G., McClinton, S., MacLennan, G.   +41 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The work of registered nurses and care assistants with older people in nursing homes: Can the outcomes be distinguished?

, 2006
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The need for Registered Nurses (RNs) in the long-term care of older people is being questioned, particularly in the context of nursing shortages, while ...
Heath, Hazel
core  

Improving standards of nutritional care on a cancer ward:the development and evaluation of a nutritional care assistant role [PDF]

, 2010
Purpose: Patients with cancer are particularly at risk of malnutrition and suffer a range of nutritional problems as a consequence of their disease and its treatment.
Ross, Fiona, Davie, Jackie, Kroll, Thilo, Wells, Mary   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Outcomes for depression and anxiety in primary care and details of treatment: a naturalistic longitudinal study

, 2011
Background There is little evidence as to whether or not guideline concordant care in general practice results in better clinical outcomes for people with anxiety and depression.
Peter FM Verhaak, Hilbink-Smolders Mirrian, Verhaak Peter FM, Penninx Brenda WJH, Hilbink-Smolders, Mirrian, Peter Spreeuwenberg, Spreeuwenberg, Peter, Bensing, Jozien M, Brenda WJH Penninx, Verhaak, P.F.M., Hilbink-Smolders, M., {Van Der Meer}, Klaas, Prins, Marijn A, van der Meer, K., Marijn A Prins, Laurant, M.G., Bensing, J.M., van der Meer Klaas, van Marwijk, H.W.J., Verhaak, P.F., van Marwijk Harm WJ, van Marwijk, Harm W. J., Prins, Marijn A., Verhaak, Peter F M, Prins, M.A., Penninx, B.W.J.H., Laurant Miranda GH, Prins Marijn A, Verhaak, Peter F. M., Klaas van der Meer, Marwijk, H.W.J. van, Spreeuwenberg Peter, Harm WJ van Marwijk, Bensing Jozien M, Van Marwijk, Harm, Penninx, Brenda W. J. H., Meer, K. van der, Spreeuwenberg, P., Laurant, Miranda G H, Laurant, Miranda G. H., Miranda GH Laurant, Penninx, Brenda W J H, Laurant, M.G.H., van der Meer, Klaas, Bensing, Jozien M., Jozien M Bensing, Mirrian Hilbink-Smolders   +46 more
core   +1 more source

Determinants of women's satisfaction with maternal health care: a review of literature from developing countries. [PDF]

, 2015
BACKGROUND: Developing countries account for 99 percent of maternal deaths annually. While increasing service availability and maintaining acceptable quality standards, it is important to assess maternal satisfaction with care in order to make it more ...
Aradhana Srivastava, Bilal I Avan, Rajbangshi, Preety, Bhattacharyya, Sanghita, Preety Rajbangshi, Sanghita Bhattacharyya, Srivastava, Aradhana, Avan, Bilal I   +7 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source