Results 111 to 120 of about 918,364 (316)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Identification of depressive disorder among older people in care homes – a feasibility study

, 2011
Background: Depression is common among older people but more common among those living in care homes. Depression is not easily detected among older adults because of the presentation, and the tendency for older people not to complain of depression ...
Shaik, K, Stephenson, John, C. Jane Morrell, Kauserjan Shaik, Muthukrishnan, Venkatesh, Curran, Stephen, Curran, S, Morrell, C. Jane, Venkatesh Muthukrishnan, Topping, Annie, Annie Topping, Morrell, CJ, Topping, A; id_orcid, John Stephenson, Muthukrishnan, V, Stephenson, J, Shaik, Kauserjan, Stephen Curran   +17 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impacto en los resultados en salud de la telesalud aplicada para la atención y seguimiento ambulatorio del alto riesgo obstétrico: revisión narrativa de la literatura

Medicina U.P.B.
Esta revisión examina la literatura sobre el impacto de la telesalud aplicada en modelos de atención en salud ambulatorios sobre los resultados en salud (funcionales, costos, satisfacción y calidad de vida) en población gestante de alto riesgo.
Sara Arango Valencia, Juan Guillermo Barrientos, Ever Augusto Torres Silva, Emmanuel Sánchez Diaz   +3 more
doaj   +1 more source

The UPBEAT nurse-delivered personalized care intervention for people with coronary heart disease who report current chest pain and depression: a randomised controlled pilot study [PDF]

, 2014
Background: Depression is common in people with coronary heart disease (CHD) and associated with worse outcome. This study explored the acceptability and feasibility of procedures for a trial and for an intervention, including its potential costs, to ...
Phillips, Rachel, Mark Haddad, van Marwijk, Harm, Van Marwijk Harm, Rachel Phillips (469282), Paul McCrone, van Marwijk, H.W.J., Barley, Elizabeth A, Barley Elizabeth A., Mark Haddad (469281), Tylee, Andre, Anthony Mann (469284), Haddad, M., Phillips Rachel, Barley, Elizabeth A., Phillips, Rachel; id_orcid, Barley, Elizabeth, Achilla, Evanthia, Mann, A., Andre Tylee, Walters, P., Anthony Mann, Tylee Andre, Elizabeth A Barley, Achilla, E., Mann, Anthony, Rachel Phillips, McCrone Paul, Barley, E. A., Van Marwijk, H., Tylee, A., Achilla Evanthia, Paul Walters (349725), Elizabeth A. Barley (573572), Harm Van Marwijk, Haddad Mark, Evanthia Achilla (573573), Paul McCrone (121370), Paul Walters, Phillips, R., Walters, Paul, Haddad, Mark, Evanthia Achilla, Walters Paul, Mann Anthony, McCrone, P., Andre Tylee (3146625), McCrone, Paul, Harm Van Marwijk (573574), Barley, E.A.   +49 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT

Health Technology Assessment
Background Functional motor disorder often causes persistent disabling symptoms that are associated with high healthcare costs. In recent years, specialist physiotherapy, informed by an understanding of functional motor disorder, has emerged as a ...
Glenn Nielsen, Louise Marston, Rachael Maree Hunter, Alan Carson, Laura H Goldstein, Kate Holt, Teresa C Lee, Marie Le Novere, Jonathan Marsden, Irwin Nazareth, Hayley Noble, Markus Reuber, Jon Stone, Ann-Marie Strudwick, Beatriz Santana Suarez, Mark J Edwards   +15 more
doaj   +1 more source

Quality of longer term mental health facilities in Europe: validation of the quality indicator for rehabilitative care against service users' views. [PDF]

, 2012
BACKGROUND: The Quality Indicator for Rehabilitative Care (QuIRC) is a staff rated, international toolkit that assesses care in longer term hospital and community based mental health facilities.
Alexiev Spiridon, Visser Ellen, Raboch Jiri, Almeida, José Miguel Barros Caldas de, Thomas Kallert, Durk Wiersma, Alexiev, Spiridon, Gonidakis, F, Cervilla Jorge A., Cardoso, Graça Maria Pereira, Caldas-de-Almeida, JM, Georgi Onchev, Mezzina Roberto, Raboch, J, Gonidakis, Fragiskos, Cervilla, Jorge A, Ridente, P, Raboch, Jiri, Visser, Ellen; id_orcid, Brangier, Paulette, Kalisova, Lucie, Patryk Piotrowski, Wiersma Durk, King, Michael, Visser, E, Kiejna, Andrzej, Penny Turton, Taylor, Tatiana L., Alexiev, S, Wright Christine, Pina Ridente, Wiersma, D, Mirjam Schuster, Ellen Visser, Christine Wright, José Miguel Caldas-de-Almeida, Tatiana L. Taylor, Killaspy, Helen, Lucie Kalisova, Brangier, P, Ploumpidis, Dimitris, Ridente, Pina, Paulette Brangier, Taylor Tatiana L., Kallert Thomas, Wright, Christine, Piotrowski, Patryk, Caldas-de-Almeida José Miguel, Helen Killaspy, Sarah White, White, S, Mezzina, R, Turton, P, Ridente Pina, Schuster, Mirjam, Jiri Raboch, Jorge A. Cervilla, Cervilla, Jorge A., Onchev, Georgi, Cardoso Graça, Kalisova, L, Visser, Ellen, Dimitris Ploumpidis, Brangier Paulette, Ploumpidis Dimitris, Kiejna Andrzej, Mezzina, Roberto, Fragiskos Gonidakis, King, M, Tatiana L Taylor, Killaspy, H, Wright, C, Taylor, Tatiana L; id_orcid, Onchev Georgi, Helen Killaspy, Kiejna, A, Ploumpidis, D, Piotrowski, P, Jorge A Cervilla, King Michael, Wiersma, Durk, Kalisova Lucie, Cardoso, Graça, Schuster, M, White Sarah, Caldas-de-Almeida, José Miguel, Schuster Mirjam, Cardoso, G, Andrzej Kiejna, Gonidakis Fragiskos, White, Sarah, Cervilla, JA, Spiridon Alexiev, Taylor, Tatiana L, Kallert, T, Piotrowski Patryk, Turton Penny, Turton, Penny, Kallert, Thomas, Taylor, TL, Onchev, G, Michael King, Roberto Mezzina, Graça Cardoso, Killaspy Helen   +104 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source