Results 121 to 130 of about 3,863,870 (310)
A Guide to Measuring Advocacy and Policy [PDF]
The overall purpose of this guide is twofold. To help grantmakers think about and talk about measurement of advocacy and policy, this guide puts forth a framework for naming outcomes associated with advocacy and policy work as well as directions for ...
Anne Gienapp +2 more
core
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Review of: "Data Interpretation in Social Research: a Guide to Standardising Research Outcomes And Outcome Evaluation" [PDF]
Abbas Riazi
openalex +1 more source
Evaluation of the Job Outcome Target Pilots: findings from the qualitative study [PDF]
This report presents the results of a qualitative evaluation of the pilot of the Job Outcome Target (JOT) in seven Jobcentre Plus Districts, covering the first six months of the pilot's operation from January to July 2005.
Johnson, S, Nunn, AE
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The National Council on Crime and Delinquency's Evaluation of the Project Development of National Institute of Corrections/Child Welfare League of America's Planning and Intervention Sites Funded to Address the Needs of Children of Incarcerated Parents [PDF]
The National Council on Crime and Delinquency (NCCD) was contracted by the Child Welfare League of America (CWLA) to conduct a process and outcome evaluation of program development for demonstration sites funded by the National Institute of Corrections ...
Stephanie Bush-Baskette, Vanessa Patino
core
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source

