Results 141 to 150 of about 8,503,104 (286)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation and the Environmental Democracy of European Cities

, 2010
Since its early days, environmental assessment aroused high expectations about its ability to insinuate ecological rationalities into worldviews, institutions, and social practices.
Alessandro Bonifazi
core  

Management-specific outcome evaluation of pituitary apoplexy; conservative and surgical approach. [PDF]

Pituitary
Guijt MC, Verstegen MJT, Zamanipoor Najafabadi AH, Bakker LEH, Notting IC, Pelsma ICM, van Furth WR, Biermasz NR, Claessen KMJA.   +8 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Outcome evaluation of percutaneous coronary intervention vs medical therapy alone in patients with chronic coronary syndrome. [PDF]

J Food Drug Anal
Chang HY, Fang HY, Huang MS, Chen YZ, Chen DY, Lai EC, Wang JD, Li YH, Ku LE.   +8 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

EVALUATION OF THE INCIDENCE AND OUTCOME OF FETAL HYDRONEPHROSIS PRENATALLY DIAGNOSED BY ULTRASOUND [PDF]

The outcome and proper management of fetal hydronephrosis have not been completely defined. The purpose of this study was to determine incidence and outcome of infants with a history of prenatal hydronephrosis diagnosed by ultrasound.
رفاهی, سهیلا, پورعیسی, مسعود, نظری, حسین   +2 more
core  

Reverse endothelial scraping technique for refractory deep infectious keratitis: Novel surgical technique and outcome evaluation. [PDF]

Indian J Ophthalmol
Udasi S, Garg A, Chauhan N, Gandhi A, Acharya M.   +4 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Goal Attainment and Outcome Evaluation for Upper and Lower Limb Spasticity: A Real-Life Cohort Analysis in a Community-Based Outreach Service. [PDF]

Toxins (Basel)
Steed A, Williams H, Alfonso J, Hancock D, Ashford SA.   +4 more
europepmc   +1 more source