Results 231 to 240 of about 8,503,104 (286)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Preventing Adolescent Suicide: Feasibility and Preliminary Outcome Evaluation of a Theatre-Based Gatekeeper Training for Teachers. [PDF]

Int J Environ Res Public Health
Davico C, Graziano F, Rossi Ghiglione A, Amianto F, Begotti T, Calandri E, Copetto G, Di Franco F, Lonardelli E, Marcotulli D, Olcuire L, Ricci F, Vitiello B.   +12 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A description and outcome evaluation of sacrococcygeal joint radiofrequency neurotomy for treatment of chronic coccydynia - A dorsal approach. [PDF]

Interv Pain Med
Moorman SW, Kutcher J, Burnham R.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Increasing the Use of Newborn Pain Treatment Following the Implementation of a Parent-Targeted Video: An Outcome Evaluation. [PDF]

Children (Basel)
Smith MA, Dunn SI, Larocque C, Wilding J, Campbell-Yeo M, Gilmore L, Harrold J, Hu J, Lavin Venegas C, Modanloo S, Nicholls SG, O'Flaherty P, Sadrudin Premji S, Reszel J, Semenic S, Squires JE, Stevens B, Trepanier MJ, Venter K, Harrison D.   +19 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study. [PDF]

BMJ Open Diabetes Res Care
Ge L, Sun Y, Tan E, Liew H, Hoe J, Lin J, Molina J, Ang G, Zhu X, Low KQ, Yap T, Azmi NASB, Yong E, Chew T, Koo HY, Law C, Chan DYS, Shi C, Choo J, Hoi WH, Chandraskear S, Lim JA, Siow J, Kaspon SB, Tavintharan S, Chew D, Abisheganaden J, Lo ZJ.   +27 more
europepmc   +1 more source

Outcome Evaluation of Three-Dimensionally Printed Patient-Specific Surgical Plates for Mandibular Reconstruction. [PDF]

Craniomaxillofac Trauma Reconstr
Zhang WB, Wang CF, Yu Y, Liu S, Hu LH, Soh HY, Zhang J, Peng X.   +7 more
europepmc   +1 more source

Outcome evaluation of dye-assist arthroscopic inside-out ganglionectomy: a retrospective study of 29 patients. [PDF]

BMC Musculoskelet Disord
Zhang F, Jiang H, Li Q, Yang H, Mi J, Rui Y, Zhao G.   +6 more
europepmc   +1 more source