Results 141 to 150 of about 3,725,551 (310)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Evaluation of the Content Validity of the COVID-19 Symptoms Daily Diary
Patient Related Outcome MeasuresJennifer Dine,1 Yanfen Guan,2 Mirline Milien,1 Claire Ervin,1 Dana D Byrne,2 Michelle L Brown,2 Carisa De Anda,2 Josephine M Norquist2 1RTI Health Solutions, Research Triangle Park, Durham, NC, USA; 2Merck & Co., Inc., Rahway, NJ, USACorrespondence ...
Dine J +7 more
doaj
Patient Related Outcome Measures, 2019 David T Eton,1,2 Roger T Anderson,3 Wendy F Cohn,3 Erin M Kennedy,3 Jennifer L St. Sauver,1,2 Bayly J Bucknell,1 Kathryn J Ruddy4 1Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; 2Robert D. and Patricia E.
Eton DT +6 more
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Impact of reslizumab on outcomes of severe asthmatic patients: current perspectives
Patient Related Outcome Measures, 2018 Alicia Padilla Galo,1,* Marina Labor,2,3,* Angelica Tiotiu,4 Ilaria Baiardini,5 Nicola Scichilone,6 Fulvio Braido7 1Unit of Pneumology, Agencia Sanitaria Costa del Sol, Marbella, Málaga, Spain; 2Department of Pulmonology, University Hospital ...
Padilla Galo A +5 more
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Remote outcome measures in Alzheimer's disease clinical trials: A call to action. [PDF]
J Prev Alzheimers DisJimenez-Maggiora GA.
europepmc +1 more source