Results 121 to 130 of about 14,326,866 (362)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Outcome measures.

, 2015
Outcome measures.
Inge Kirchberger (334352), Rolf Holle (262610), Matthias Hunger (712921), Hildegard Seidl (712922), Björn Stollenwerk (294995), Bernhard Kuch (712924), Katrin Burkhardt (712923), Christa Meisinger (39940)   +7 more
core   +2 more sources

Measuring medicine-related experiences from the patient perspective: a systematic review

Patient Related Outcome Measures, 2016
Barbra Katusiime,1 Sarah Corlett,1 Joanne Reeve,2 Janet Krska1 1Medway School of Pharmacy, The Universities of Kent and Greenwich, Chatham, Maritime, Kent, UK; 2Warwick Medical School, University of Warwick, Coventry, UK Background: There is an ...
Katusiime B, Corlett S, Reeve J, Krska J
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Systematic Literature Review of Studies Reporting Measures of Functional Outcome or Quality of Life in People with Negative Symptoms of Schizophrenia

Patient Related Outcome Measures
Dusica Hadzi Boskovic,1 Jayne Smith-Palmer,2 Johannes Pöhlmann,2 Richard F Pollock,2 Steve Hwang,1 David Bruhn1 1Global Value and Real World Evidence, Otsuka Pharmaceutical Development & Commercialization Inc, Princeton, NJ, USA; 2Covalence Research Ltd,
Hadzi Boskovic D, Smith-Palmer J, Pöhlmann J, Pollock RF, Hwang S, Bruhn D   +5 more
doaj  

Construct domain analysis of patient health-related quality of life: physical and mental trajectory profiles following open versus endovascular repair of abdominal aortic aneurysm

Patient Related Outcome Measures, 2012
Nicolas J Mouawad, Stefan W Leichtle, Jeffrey V Manchio, Richard M Lampman, Brian G Halloran, Walter M Whitehouse JrMichigan Heart and Vascular Institute, Saint Joseph Mercy Health System, Ann Arbor, MI, USAPurpose: Many clinical trials comparing the ...
Mouawad NJ, Leichtle SW, Manchio JV, Lampman RM, Halloran BG, Whitehouse Jr WM   +5 more
doaj  

Outcome measurements in orthopedic

Indian Journal of Orthopaedics, 2007
The choice of outcome measure in orthopedic clinical research studies is paramount. The primary outcome measure for a study has several implications for the design and conduct of the study. These include: 1) sample size determination, 2) internal validity, 3) compliance and 4) cost.
Bhandari, Mohit, Petrisor, Brad, Schemitsch, Emil   +2 more
openaire   +3 more sources

Upper Limb Outcome Measures Used in Stroke Rehabilitation Studies: A Systematic Literature Review

PLoS ONE, 2016
Background Establishing which upper limb outcome measures are most commonly used in stroke studies may help in improving consensus among scientists and clinicians.
L. Santisteban, M. Teremetz, J. Bleton, J. Baron, M. Maier, P. Lindberg   +5 more
semanticscholar   +1 more source

Preface: An evolving perspective of mental health outcome measures

, 2010
mental health outcome ...
TANSELLA, Michele, Thornicroft G.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source