Results 101 to 110 of about 14,326,866 (362)

Outcome Measures in Clinical Trials for Multiple Sclerosis

CNS Drugs, 2017
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess the true efficacy of interventions in clinical trials. In phase
C. V. van Munster, B. Uitdehaag
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

User preference for a portable syringe pump for iloprost infusion

Patient Related Outcome Measures, 2015
Antonella Laria,1 Alfredo Maria Lurati,1 Katia Angela Re,1 Maria Grazia Marrazza,1 Daniela Mazzocchi,1 Alberto Farina,2 Magda Scarpellini,1 1Department of Rheumatology, Fornaroli Hospital, Magenta, Milan, Italy; 2Medical Affairs Department, Italfarmaco S.
Laria A, Lurati AM, Re KA, Marrazza MG, Mazzocchi D, Farina A, Scarpellini M   +6 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Prevalence, Clinical Characteristics and Determinants of Unsuccessful Treatment Outcomes Among Pulmonary Tuberculosis Patients: A 5-Year Registry-Based Retrospective Cohort Study

Patient Related Outcome Measures
Hind M AlOsaimi,1 Mohammed K Alshammari,2 Ghadah K Almijlad,3 Nawaf M Alotaibi,3 Dhafer A Alqahtani,4 Mohammed M Alshamrani,5 Tariq A Shutur,6 Mansior F Alhazmi,6 Mohammed A Hurubi,6 Kutayd S ALShammari,6 Khalid M Alzahrani,7 Hadeel M Aldaghriri,7 Anood ...
AlOsaimi HM, Alshammari MK, Almijlad GK, Alotaibi NM, Alqahtani DA, Alshamrani MM, Shutur TA, Alhazmi MF, Hurubi MA, ALShammari KS, Alzahrani KM, Aldaghriri HM, Alshammari AA, Alatawi OS, Alharbi RA   +14 more
doaj  

Improving communication between the physician and the COPD patient: an evaluation of the utility of the COPD Assessment Test in primary care

Patient Related Outcome Measures, 2014
Shahrzad M Lari, Davood Attaran, Mohammad TohidiCOPD Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAbstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide.
Lari SM, Attaran D, Tohidi M
doaj  

Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

, 2013
Background: linical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap ...
Haviland, J.S., Betambeau, N., Balta, V., Reece-Smith, A., Benson, J., Winters, Z.E.   +5 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer

Nature Reviews Clinical Oncology, 2021
E. Fokas, A. Appelt, R. Glynne-Jones, G. Beets, R. Perez, J. García-Aguilar, E. Rullier, J. Smith, C. Marijnen, F. Peters, Maxine van der Valk, R. Beets-Tan, A. Myint, J. Gérard, S. Bach, M. Ghadimi, R. Hofheinz, K. Bujko, C. Gani, K. Haustermans, B. Minsky, E. Ludmir, N. West, M. Gambacorta, V. Valentini, M. Buyse, A. Renehan, A. Gilbert, D. Sebag‐Montefiore, C. Rödel   +29 more
semanticscholar   +1 more source

Outcome measures in coeliac disease trials: the Tampere recommendations

Gut, 2018
Objective A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies.
J. Ludvigsson, C. Ciacci, P. Green, K. Kaukinen, I. Korponay-Szabó, K. Kurppa, J. Murray, K. Lundin, M. Maki, A. Popp, Norelle R. Reilly, A. Rodríguez-Herrera, D. Sanders, D. Schuppan, S. Sleet, Juha Taavela, Kristin N. Voorhees, M. Walker, D. Leffler   +18 more
semanticscholar   +1 more source