Results 31 to 40 of about 204,602 (199)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Functional Versatility of Vibrio cholerae Outer Membrane Proteins

Applied Microbiology
A key feature that differentiates Gram-positive and Gram-negative bacteria is the outer membrane, an asymmetric membrane composed of lipopolysaccharides, phospholipids, lipoproteins and integral proteins, including the outer-membrane proteins (OMPs).
Annabelle Mathieu-Denoncourt, Marylise Duperthuy   +1 more
doaj   +1 more source

On Issues of Labelling in the Dictionnaire Français–Mpongwé: A Case-study

Lexikos, 2011
<p>ABSTRACT: Dictionaries contain lexicographic data whose occurrence is restricted to certain geo-graphical areas, subject fields, professions, etc.
P.A. Mavoungou
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Unveiling the role of BON domain-containing proteins in antibiotic resistance

Frontiers in Microbiology
The alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access.
Shengwei Sun, Jinju Chen
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Host-adaptation of Francisella tularensis alters the bacterium's surface-carbohydrates to hinder effectors of innate and adaptive immunity.

PLoS ONE, 2011
BackgroundThe gram-negative bacterium Francisella tularensis survives in arthropods, fresh water amoeba, and mammals with both intracellular and extracellular phases and could reasonably be expected to express distinct phenotypes in these environments ...
Tiffany M Zarrella, Anju Singh, Constantine Bitsaktsis, Tabassum Rahman, Bikash Sahay, Paul J Feustel, Edmund J Gosselin, Timothy J Sellati, Karsten R O Hazlett   +8 more
doaj   +1 more source

Operational challenges that may affect implementation of evidence-based mobile market interventions

BMC Public Health, 2022
Introduction Mobile produce markets are becoming an increasingly prevalent, accepted, and effective strategy for improving fruit and vegetable (F&V) access and consumption across underserved and lower-income communities.
Christina M. Kasprzak, Anne E. Lally, Julia J. Schoonover, Deanna Gallicchio, Lindsey Haynes-Maslow, Leah N. Vermont, Alice S. Ammerman, Samina Raja, Laurene Tumiel-Berhalter, Jill N. Tirabassi, Lucia A. Leone   +10 more
doaj   +1 more source

C-Band SAR Winds for Tropical Cyclone Monitoring and Forecast in the South-West Indian Ocean

Atmosphere, 2021
Tropical cyclone (TC) monitoring and forecast in the South West Indian Ocean (SWIO) basin remain challenging, notably because of the lack of direct observations.
Quoc-Phi Duong, Sébastien Langlade, Christophe Payan, Romain Husson, Alexis Mouche, Sylvie Malardel   +5 more
doaj   +1 more source