Results 51 to 60 of about 501,776 (290)

Apollonian Packing of Circles within Ellipses

Algorithms, 2023
The purpose of a circle packing procedure is to fill up a predefined, geometrical, closed contour with a maximum finite number of circles. The subject has received considerable attention in pure and applied sciences and has proved to be highly effective ...
Carlo Santini, Fabio Mangini, Fabrizio Frezza   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A Novel Planar Fractal Antenna with CPW-Feed for Multiband applications [PDF]

, 2013
In this paper, a multiband antenna using a novel fractal design is presented. The antenna structure is formed by inscribing a hexagonal slot within a circle.
Joseph, S., Mohanan, P., Mridula, S., Paul, B.   +3 more
core   +1 more source

The Eccentric Cavity, Triple Rings, Two-armed Spirals, and Double Clumps of the MWC 758 Disk [PDF]

, 2018
Spatially resolved structures in protoplanetary disks hint at unseen planets. Previous imaging observations of the transitional disk around MWC 758 revealed an inner cavity, a ring-like outer disk, emission clumps, and spiral arms, all possibly generated
Akiyama, Eiji, Andrews, Sean, Casassus, Simon, Chiang, Eugene, Dong, Ruobing, Eisner, Josh, Esposito, Thomas, Fung, Jeffrey, Hasegawa, Yasuhiro, Hashimoto, Jun, Liu, Hauyu Baobab, Liu, Sheng-yuan, Muto, Takayuki, Pavlyuchenkov, Yaroslav, Tamura, Motohide, Wilner, David, Wisniewski, John, Zhu, Zhauhuan   +17 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Radial mixing and the transition between the thick and thin Galactic discs

, 2008
The analysis of the kinematics of solar neighbourhood stars shows that the low and high metallicity tails of the thin disc are populated by objects which orbital properties suggest an origin in the outer and inner galactic disc, respectively.
Arifyanto, Bensby, Bensby, Bensby, Binney, Brook, Carney, Chen, De Simone, Demarque, Edvardsson, Famaey, Famaey, Fuhrmann, Gilli, Gilmore, Grenon, Haywood, Helmi, Jørgensen, Lépine, M. Haywood, Minchev, Mishenina, Navarro, Nordström, Reddy, Reddy, Roškar, Sellwood, Soubiran, Valenti, Wielen, Wielen, Wyse, Yong   +35 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Differences in equine spinal kinematics between straight line and circle in trot

Scientific Reports, 2021
Work on curved tracks, e.g. on circles, is commonplace within all forms of horse training. Horse movements in circles are naturally asymmetric, including the load distribution between inner and outer limbs.
A. Byström, A. M. Hardeman, F. M. Serra Bragança, L. Roepstorff, J. H. Swagemakers, P. R. van Weeren, A. Egenvall   +6 more
doaj   +1 more source

Outer and expanding circle Englishes

English World-Wide. A Journal of Varieties of English, 2015
The classification of English as a native (ENL), second (ESL) and foreign (EFL) language is traditionally mapped onto Kachru’s (1985) Inner, Outer and Expanding circles, respectively. This paper addresses the divide upheld between these different varietal types.
Edwards, Alison, Laporte, Samantha
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source