Results 51 to 60 of about 502,709 (294)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Trilingual and Multicultural Experiences Mitigating Students’ Linguistic Stereotypes: Investigating the Perceptions of Undergraduates of Chinese Heritage Regarding Native/Non-Native English Teachers

open access: yesBehavioral Sciences, 2023
Student stereotyping of non-native English-speaking teachers is a common focus of research and there is a paucity of studies targeting trilingual students of multicultural backgrounds.
Minmin Yang   +2 more
doaj   +1 more source

Tracing the Spiral Structure of the Outer Milky Way with Dense Atomic Hydrogen Gas

open access: yes, 2017
We present a new face-on map of dense neutral atomic hydrogen (HI) gas in the outer Galaxy. Our map has been produced from the Leiden/Argentine/Bonn (LAB) HI 21-cm line all-sky survey by finding intensity maxima along every line of sight and then by ...
Balser, Dana S.   +6 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Global English and World Englishes From an Evolutionary Perspective: A Rejoinder to Anna Kristina Hultgren

open access: yesNJES: Nordic Journal of English studies, 2020
The terms Global English and World Englishes reflect two opposite imperial perspectives. The first highlights the success of the British Empire in spreading the language of England to various corners of the world, whereas the second subverts the race ...
Salikoko S. Mufwene
doaj   +1 more source

Apollonian Packing of Circles within Ellipses

open access: yesAlgorithms, 2023
The purpose of a circle packing procedure is to fill up a predefined, geometrical, closed contour with a maximum finite number of circles. The subject has received considerable attention in pure and applied sciences and has proved to be highly effective ...
Carlo Santini   +2 more
doaj   +1 more source

Outer and expanding circle Englishes

open access: yesEnglish World-Wide. A Journal of Varieties of English, 2015
The classification of English as a native (ENL), second (ESL) and foreign (EFL) language is traditionally mapped onto Kachru’s (1985) Inner, Outer and Expanding circles, respectively. This paper addresses the divide upheld between these different varietal types.
Edwards, Alison, Laporte, Samantha
openaire   +3 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Analisis Kesulitan Melukis Lingkaran Dalam dan Lingkaran Luar Suatu Segitiga pada Materi Garis Singgung Lingkaran Siswa Kelas VIII Semester II MTs Negeri Gondangrejo Tahun Pelajaran 2014/2015 [PDF]

open access: yes, 2015
The purpose of this study was to determine the difficulties experienced by students and the cause of the difficulties experienced by students in the drawing and understand the inner circle and outer circle of a triangle.
, Dr. H. Sumardi, M. Si.   +1 more
core  

The real part of an outer function and a Helson-Szeg weight [PDF]

open access: yes, 2000
Suppose F is a nonzero function in the Hardy space H1. We study the set {f ; f is outer and !Fl ::; Re f a.e. on 8D} where 8D is a unit circle. When F is a strongly outer function in H1 and 'Y is a positive constant, we describe the set {!
Nakazi, T, Yamamoto, T
core   +1 more source

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