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Outer membrane protein evolution
Current Opinion in Structural Biology, 2021Outer membrane proteins have remarkably homogeneous structure. They are all up down β-barrels. Up down barrels themselves are composed of repeated sets of β-hairpins. The consistency of the usage of the β-hairpin throughout the outer membrane milieu allows for interrogation of the evolution of these repetitive structures.
Rik, Dhar, Joanna Sg, Slusky
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Cracking outer membrane biogenesis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023The outer membrane is a distinguishing feature of the Gram-negative envelope. It lies on the external face of the peptidoglycan sacculus and forms a robust permeability barrier that protects extracytoplasmic structures from environmental insults. Overcoming the barrier imposed by the outer membrane presents a significant hurdle towards developing novel
Randi L, Guest, Thomas J, Silhavy
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EcoSal Plus, 2005
Outer membrane vesicles (blebs) are produced by Escherichia coli , Salmonella , and all other gram-negative bacteria both in vitro and in vivo. Most of the research in the field has focused on the properties of vesicles derived from pathogenic bacteria and their interactions with eukaryotic ...
Amanda J, McBroom, Meta J, Kuehn
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Outer membrane vesicles (blebs) are produced by Escherichia coli , Salmonella , and all other gram-negative bacteria both in vitro and in vivo. Most of the research in the field has focused on the properties of vesicles derived from pathogenic bacteria and their interactions with eukaryotic ...
Amanda J, McBroom, Meta J, Kuehn
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2019
The transport of small molecules across membranes is essential for the import of nutrients and other energy sources into the cell and, for the export of waste and other potentially harmful byproducts out of the cell. While hydrophobic molecules are permeable to membranes, ions and other small polar molecules require transport via specialized membrane ...
Masi, Muriel +2 more
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The transport of small molecules across membranes is essential for the import of nutrients and other energy sources into the cell and, for the export of waste and other potentially harmful byproducts out of the cell. While hydrophobic molecules are permeable to membranes, ions and other small polar molecules require transport via specialized membrane ...
Masi, Muriel +2 more
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Outer Membrane Protein Purification
2003The major outer membrane proteins (OMPs) from Neisseria meningitidis, which are expressed at high levels, are subdivided in five classes based on molecular weight (1,2) (see Table 1). Table 1 Major Meningococcal Outer-Membrane Proteins Outer-membrane proteins Name Molecular maass Function/characteristics Class 1 PorA 44-47 kDa Porin Class 2/3 PorB 37 ...
Arigita, C +3 more
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1998
Pseudomonas aeruginosa is a gram-negative bacterium and as such has an outer membrane. The general functions of the outer membrane include size-dependent exclusion of larger molecules, permitting selective permeability of smaller molecules, uptake of large and small polycations, specific facilitated uptake of certain substrates, export of excreted ...
Robert E. W. Hancock +1 more
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Pseudomonas aeruginosa is a gram-negative bacterium and as such has an outer membrane. The general functions of the outer membrane include size-dependent exclusion of larger molecules, permitting selective permeability of smaller molecules, uptake of large and small polycations, specific facilitated uptake of certain substrates, export of excreted ...
Robert E. W. Hancock +1 more
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Methanotroph Outer Membrane Preparation
2011All presently known methanotrophs are gram-negative bacteria suggesting that they are surrounded by a two-layered membrane: an inner or cytoplasmic membrane and an outer membrane. In the methanotroph Methylococcus capsulatus (Bath), separation of the two membranes has allowed studies on protein and lipid composition of the outer membrane.
Odd A, Karlsen +3 more
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Assembling the mitochondrial outer membrane
Nature Structural & Molecular Biology, 2004The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins ...
Pfanner, Nikolaus +3 more
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Alterations in Outer Membrane Permeability
Annual Review of Microbiology, 1984INTRODucnON ... ......... .. . .. ........ ... ........ . .. .. ... .. ... . ......... .. ........ . 238 Structure oj the Cell Envelope 238 Uptake Arross the Outer Membrane 239 Intrinsic,Dejects in Outer Membrane Permeability in So.me Bacteria . .... ..... .. .... .. 241 MUTATIONAL ALTERATIONS IN OUTER MEMBRANE PERMEABILITy .........
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2010
The outer membrane is considered to be a barrier in Gram-negative bacteria. However, bacteria are not autonomous and have to communicate in many ways with their surroundings. This interaction ranges from their association to surfaces, uptake of solutes, and sensing of environmental conditions to export of solutes into attacked cells.
Oliver Mirus +2 more
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The outer membrane is considered to be a barrier in Gram-negative bacteria. However, bacteria are not autonomous and have to communicate in many ways with their surroundings. This interaction ranges from their association to surfaces, uptake of solutes, and sensing of environmental conditions to export of solutes into attacked cells.
Oliver Mirus +2 more
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