Results 281 to 290 of about 590,456 (352)

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Exploring the genomic landscape of Chlamydiifrater species: novel features include multiple truncated major outer membrane proteins, unique genes and chlamydial plasticity zone orthologs. [PDF]

Access Microbiol
Hölzer M, Reuschel C, Vorimore F, Laroucau K, Sachse K.   +4 more
europepmc   +1 more source

Synthesis and intracellular transport of mitochondrial proteins [PDF]

, 1985
A Lustig, A Lustig, A Ohashi, A Viebrock, AJ Lamb, AP Autor, AS Lewin, AS Lewin, B Hennig, B Schmidt, BE Roberts, BG Barrell, C Cote, C Zwizinski, CJ Leaver, DI Meyer, DI Meyer, DL Stigall, DM Kolansky, E Komar, E Marra, E Pratje, E Schmelzer, G Attardi, G Blobel, G Daum, G Daum, G Hallermayer, G Hallermayer, G Kreibich, G Kreil, G Macino, G Reid, G Schatz, G Schatz, G Schatz, G Srivastava, GC Shore, GC Shore, H Freitag, H Koehler, H Korb, H Riezman, H Weiss, IG Macreadie, IZ Ades, IZ Ades, J Kaput, JG Conboy, JP Kraus, K Mihara, K Mihara, K Mihara, K Watanabe, L Ernster, L Randall, LA Grivell, LE Aziz, M Inouye, M Klingenberg, M Klingenberg, M Maccechini, M Mori, M Mori, M Schleyer, M Suissa, M Teintze, M Wikstrom, M Yamamoto, M-L Maccechini, MA Harmey, MA Harmey, MD Hampsey, MM Mueckler, N Cerletti, N Nabi, N Nelson, NK Bhat, P Boehni, P Boehni, P Boogart van den, P Borst, P Borst, P Borst, P McAda, P Sonderegger, P Walter, PC Heinrich, PC Kreibich, PG Adolphus, R Jaussi, R Michel, R Sakakibara, R Zimmermann, R Zimmermann, R Zimmermann, R Zimmermann, RE Kellems, RE Kellems, RO Poyton, S Matsuura, S Miura, S Passarella, S Werner, SD Emr, SM Gasser, SM Gasser, SM Gasser, T Hunt, T Monta, T Oda, VA Rucker, W Neupert, W Wickner, Y Kamisaki, Y Raymond, Y Sagara, Y Yoshida   +117 more
core   +1 more source

Mutations altering the cellular localization of the phage lambda receptor, an Escherichia coli outer membrane protein.

, 1978
Scott D. Emr, Martin A. Schwartz, Thomas J. Silhavy   +2 more
openalex   +2 more sources

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F. [PDF]

PLoS One
Igomu EE, Mamman PH, Adamu J, Muhammad M, Woziri AO, Sugun MY, Benshak JA, Anyika KC, Sam-Gyang R, Ehizibolo DO.   +9 more
europepmc   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

<i>Helicobacter pylori</i> Outer Membrane Proteins and Virulence Factors: Potential Targets for Novel Therapies and Vaccines. [PDF]

Pathogens
Sedarat Z, Taylor-Robinson AW.
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Species identification and phenotypic analysis of the expression of outer membrane proteins in clinical and hospital wastewater isolates of Acinetobacter sp

, 2014
Karine Lena Meneghetti
openalex   +1 more source