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Outer Membrane Biogenesis [PDF]
Annual Review of Microbiology, 2017 The hallmark of Gram-negative bacteria and organelles such as mitochondria and chloroplasts is the presence of an outer membrane (OM). In bacteria such as Escherichia coli, the OM is a unique asymmetric lipid bilayer with lipopolysaccharide (LPS) in the ...
Anna Konovalova +2 more
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Physical properties of the bacterial outer membrane
Nature Reviews Microbiology, 2021 It has long been appreciated that the Gram-negative outer membrane acts as a permeability barrier, but recent studies have uncovered a more expansive and versatile role for the outer membrane in cellular physiology and viability.
Steven T Rutherford +2 more
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Outer membrane vesicle vaccines. [PDF]
Seminars in Immunology, 2020 Outer Membrane Vesicles (OMV) have received increased attention in recent years as a vaccine platform against bacterial pathogens. OMV from Neisseria meningitidis serogroup B have been extensively explored.
F. Micoli, C. MacLennan
semanticscholar +3 more sources
Phase separation in the outer membrane of Escherichia coli
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Antimicrobial resistance is particularly prevalent in gram-negative bacteria, as antibiotics that act inside the cells must overcome their outer membrane.
Georgina Benn +2 more
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Bacterial outer membrane constriction [PDF]
Molecular Microbiology, 2018 SummaryThe outer membrane of Gram‐negative bacteria is a crucial permeability barrier allowing the cells to survive a myriad of toxic compounds, including many antibiotics. This innate form of antibiotic resistance is compounded by the evolution of more active mechanisms of resistance such as efflux pumps, reducing the already limited number of ...
Alexander J F Egan
semanticscholar +4 more sources
The Treponema pallidum Outer Membrane [PDF]
Current Topics in Microbiology and Immunology, 2017 The outer membrane (OM) of Treponema pallidum, the uncultivatable agent of venereal syphilis, has long been the subject of misconceptions and controversy. Decades ago, researchers postulated that T.
J. Radolf, Sanjiv Kumar
semanticscholar +3 more sources
Breaking the outer membrane barrier: structure, targets, and antimicrobial strategies for Gram-negative bacteria [PDF]
Frontiers in MicrobiologyMultidrug resistance in Gram-negative bacteria has become a significant global public health challenge, threatening human health and clinical treatment outcomes. The unique outer membrane structure of these pathogens greatly limits antibiotic penetration,
Fanzhuo Xu +3 more
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Understanding antibiotic resistance via outer membrane permeability
Infection and Drug Resistance, 2018 Ishan Ghai,1,2 Shashank Ghai3 1School of Engineering and Life Sciences, Jacobs University, Bremen, Germany; 2Consultation Division, RSGBIOGEN, New Delhi, India; 3Leibniz University Hannover, Hannover, Germany Abstract: Collective antibiotic drug ...
Ghai I, Ghai S
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A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria
Nature Communications, 2016 Bacteria release outer membrane vesicles (OMVs) that play important roles in pathogenesis and intercellular interactions. Here, Roier et al. provide evidence supporting that phospholipid accumulation in the outer leaflet of the outer membrane ...
Sandro Roier +14 more
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mBio, 2016 The Gram-negative outer membrane is an important barrier that provides protection against toxic compounds, which include antibiotics and host innate immune molecules such as cationic antimicrobial peptides.
Samuel I. Miller
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