Results 41 to 50 of about 2,014,126 (252)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A bacterial membrane sculpting protein with BAR domain-like activity
eLife, 2021 Bin/Amphiphysin/RVS (BAR) domain proteins belong to a superfamily of coiled-coil proteins influencing membrane curvature in eukaryotes and are associated with vesicle biogenesis, vesicle-mediated protein trafficking, and intracellular signaling. Here, we
Daniel A Phillips +13 more
doaj +1 more source
Characterization of the protein import apparatus in isolated outer envelopes of chloroplasts [PDF]
, 1991 Isolated outer envelope membrane from pea (Pisum sativum L.) chloroplasts can be used in vitro to study binding and partial translocation of precursor proteins destined for the inside of the organelle.
Soll, Jürgen, Waegemann, Karin
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Helicobacter pylori Outer Membrane Protein-Related Pathogenesis
Toxins, 2017 Helicobacter pylori colonizes the human stomach and induces inflammation, and in some cases persistent infection can result in gastric cancer. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and outer membrane ...
Yuichi Matsuo +2 more
doaj +1 more source
High yield production process for Shigella outer membrane particles. [PDF]
PLoS ONE, 2012 Gram-negative bacteria naturally shed particles that consist of outer membrane lipids, outer membrane proteins, and soluble periplasmic components. These particles have been proposed for use as vaccines but the yield has been problematic.
Francesco Berlanda Scorza +11 more
doaj +1 more source
A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of T. brucei
Life Science Alliance, 2023 Disruption of mitochondrial outer membrane protein biogenesis triggers a pathway leading to proteasomal degradation of orphan outer membrane proteins mediated by Msp1 and three interacting proteins.
Markus Gerber +7 more
doaj +1 more source
Prediction of β-barrel membrane proteins by searching for restricted domains [PDF]
, 2005 BACKGROUND: The identification of beta-barrel membrane proteins out of a genomic/proteomic background is one of the rapidly developing fields in bioinformatics. Our main goal is the prediction of such proteins in genome/proteome wide analyses.
Mirus, O. +5 more
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Analysis of outer membrane vesicle associated proteins isolated from the plant pathogenic bacterium Xanthomonas campestris pv. campestris [PDF]
, 2008 Sidhu VK, Vorhölter F-J, Niehaus K, Watt SA. Analysis of outer membrane vesicle associated proteins isolated from the plant pathogenic bacterium Xanthomonas campestris pv. campestris. BMC Microbiology.
Steven A Watt +11 more
core +1 more source