Results 61 to 70 of about 301,015 (306)

United Nations Treaties and Principles on Outer Space [PDF]

open access: yes, 2008
The progressive development and codification of international law constitutes one of the principal responsibilities of the United Nations in the legal field.
United Nations Office for Outer Space Affairs
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

The sky's the limit? Establishing a legal delimitation of airspace and outer space [PDF]

open access: yes, 2008
The debate over the legal delimitation between air and space has been argued for over half a century. In representing the positions of those concerned one can show the need for a boundary between airspace and outer space.
Monahan, Rhys
core  

Analysis of Solar Neutrino Data from Super-Kamiokande I and II

open access: yesEntropy, 2014
We are going back to the roots of the original solar neutrino problem: the analysis of data from solar neutrino experiments. The application of standard deviation analysis (SDA) and diffusion entropy analysis (DEA) to the Super-Kamiokande I and II data ...
Hans J. Haubold   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The Legal Dimension of the State Activities in Outer Space: the Draft Code of Conduct in Outer Space Activities [PDF]

open access: yes, 2013
in the last decade several initiatives have been launched at the international level to face the challenge of space sustainability through soft law instruments. The first basket is composed by the technical set of rules adopted for space debris .
MARCHISIO, Sergio
core  

Pathway to Fractional Integrals, Fractional Differential Equations, and Role of the H-Function

open access: yesAxioms
In this paper, the pathway model for the real scalar variable case is re-explored and its connections to fractional integrals, solutions of fractional differential equations, Tsallis statistics and superstatistics in statistical mechanics, the reaction ...
Arak M. Mathai, Hans J. Haubold
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Peckham Outer-Space Initiative [PDF]

open access: yes, 2011
"In Ships Not Shelters, the Peckham Outer-Space Initiative (POI) has produced a publication creatively renouncing the stasis inherent in the idea of a shelter, and instead embracing the ship as a vehicle (physically, mentally) for some diagonal forward ...
Feo, Roberto   +3 more
core  

Sustainable development and scientific research in outer space [PDF]

open access: yes, 2022
The interpretation of the ”interest of mankind” principle has led, first, to the adoption of the Moon Agreement and, at the same time, brought to its defeat.
De Maestri Maria Elena
core  

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