Results 51 to 60 of about 521,903 (288)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

USE OF ARTIFICIAL NEURAL NETWORKS FOR MODELING INFLOW AND OUTFLOW AND SALINITY OF LAKE FETZARA IN THE REGION-ANNABA (NE ALGERIA)

Food and Environment Safety, 2022
Lake Fetzara is one of the important lakes in the northeast of Algeria; the water supplying this lake comes from different precipitation and wadis. Moreover, Meboudja wadi constitutes the drainage channel.
Zahra BOUHALI, Larbi DJABRI, Hamza BOUGUERRA, Fatma TRABELSI, Azzedine HANI, Hicham CHAFFAI   +5 more
doaj  

Discovery of the Youngest Molecular Outflow associated with an Intermediate-mass protostellar Core, MMS-6/OMC-3

, 2011
We present sub-arcsecond resolution HCN (4-3) and CO (3-2) observations made with the Submillimeter Array (SMA), toward an extremely young intermediate-mass protostellar core, MMS 6-main, located in the Orion Molecular Cloud 3 region (OMC-3).
Arce, Aso, Bachiller, Bachiller, Bontemps, Bourke, Chini, Hirano, Ho, Hogerheijde, Johnstone, Lee, Lee, Lis, Machida, Matthews, Phan-Bao, Phan-Bao, Pineda, Pudritz, Shang, Shang, Takahashi, Takahashi, Takahashi, Williams, Zapata   +26 more
core   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Hourglass Magnetic Field of a Protostellar System

Universe
An hourglass-shaped magnetic field pattern arises naturally from the gravitational collapse of a star-forming gas cloud. Most studies have focused on the prestellar collapse phase, when the structure has a smooth and monotonic radial profile.
Shantanu Basu, Xiyuan Li, Gianfranco Bino   +2 more
doaj   +1 more source

Rotating molecular outflows: the young T Tauri star in CB26

, 2008
The disk-outflow connection is thought to play a key role in extracting excess angular momentum from a forming proto-star. Though jet rotation has been observed in a few objects, no rotation of molecular outflows has been unambiguously reported so far ...
A. Dutrey, Anderson, Anglada, Artymowicz, Bacciotti, Bacciotti, Bisschop, Chen, Chrysostomou, Cieza, Codella, Coffey, Coffey, D. Semenov, Downes, Dutrey, F. Gueth, Gueth, Guilloteau, Guilloteau, Gullbring, Haisch, Hartigan, Henning, K. Schreyer, Lada, Launhardt, Launhardt, Lee, Lee, Lenzen, Masciadri, Ossenkopf, Pavlyuchenkov, Pety, R. Launhardt, Richer, Rodríguez, S. Guilloteau, Shu, Siess, Simon, Stecklum, Terquem, Th. Henning, V. Piétu, Woitas, Wolf, X. Chen, Ya. Pavlyuchenkov   +49 more
core   +3 more sources

Tracing the Bipolar Outflow from Orion Source I [PDF]

, 2009
Using CARMA, we imaged the 87 GHz SiO v=0 J=2-1 line toward Orion-KL with 0.45 arcsec angular resolution. The maps indicate that radio source I drives a bipolar outflow into the surrounding molecular cloud along a NE--SW axis, in agreement with the model
A. D. Bolatto, Chandler, Cunningham, D. N. Friedel, D. P. Woody, Doeleman, Doi, Gezari, Greenhill, Gómez, J. W. Lamb, M. C. H. Wright, M. W. Pound, R. L. Plambeck, Rodríguez, S. L. Scott, S. L. Widicus Weaver, Sandstrom, Terquem, Wright, Zapata   +20 more
core   +2 more sources

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Measurement of Outflow Facility Using iPerfusion. [PDF]

PLoS ONE, 2016
Elevated intraocular pressure (IOP) is the predominant risk factor for glaucoma, and reducing IOP is the only successful strategy to prevent further glaucomatous vision loss.
Joseph M Sherwood, Ester Reina-Torres, Jacques A Bertrand, Barnaby Rowe, Darryl R Overby   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source