Results 51 to 60 of about 531,231 (335)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The Influences of Outflow on the Dynamics of Inflow

, 2008
Both numerical simulations and observations indicate that in an advection-dominated accretion flow most of the accretion material supplied at the outer boundary will not reach the inner boundary. Rather, they are lost via outflow.
Blandford R. D., Feng Yuan, Fu‐Guo Xie, Paczynski B., Shakura N. I., Silk J.   +5 more
core   +1 more source

Mass-losing accretion discs around supermassive black holes [PDF]

, 2008
We study the effects of outflow/wind on the gravitational stability of accretion discs around supermassive black holes using a set of analytical steady-state solutions.
A. Merloni, A. Toomre, C. Combet, C. Knigge, D. Proga, E. Quataert, F. Khajenabi, F. Khajenabi, G. Pelletier, I. Shlosman, J. Fukue, J. Goodman, J. Goodman, J.C. Tan, K.-Y. Watarai, K.M. Leighly, K.M. Leighly, N. Murray, N.I. Shakura, R. Ganguly, R. Misra, R. Turolla, R.D. Blandford, R.E. Taam, R.P. Fender, S. Nayakshin, T. Beckert, V. Das, V. Das, Y. Levin   +29 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

An Increase in the Energy Efficiency of Vortex Micro HPP with a Flexible Outlet Siphon by Self-Adjustment of Flows in the Pressure Chamber

Журнал інженерних наук
The article aims to increase the energy efficiency of the vortex micro-power plant, which would be achieved due to its compatibility with the terrain. In particular, the inlet channel connected to the water intake of the pressure chamber and the water ...
Omari Zivzivadze, Archil Geguchadze, Badri Zivzivadze, David Dzadzamia, Anzori Kuparadze, Nata Sulakvelidze   +5 more
doaj   +1 more source

The impact of the warm outflow in the young (GPS) radio source & ULIRG PKS 1345+12 (4C 12.50) [PDF]

, 2010
(Abridged) We present new deep VLT/FORS optical spectra with intermediate resolution and large wavelength coverage of the GPS radio source and ULIRG PKS1345+12 (4C12.50; z=0.122), taken with the aim of investigating the impact of the nuclear activity on ...
Emonts, B. H. C., Holt, J., Morganti, R., Tadhunter, C. N.   +3 more
core   +5 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A search for 95 GHz class I methanol masers in molecular outflows

, 2012
We have observed a sample of 288 molecular outflow sources including 123 high-mass and 165 low-mass sources to search for class I methanol masers at 95 GHz transition and to investigate relationship between outflow characteristics and class I methanol ...
Chen, Xi, Gan, Cong-Gui, Ju, Bing-Gang, Shen, Zhi-Qiang, Xu, Ye   +4 more
core   +1 more source

Galactic cluster winds in presence of a dark energy [PDF]

, 2013
We obtain a solution for the hydrodynamic outflow of the polytropic gas from the gravitating center, in presence of the uniform Dark Energy (DE).
Bisnovatyi-Kogan, G. S., Merafina, M.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source