Results 51 to 60 of about 168,432 (316)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Cerebral arterial collateral status, but not venous outflow profiles, modifies the effect of intravenous tissue plasminogen activator in acute ischemic stroke

Brain Circulation
BACKGROUND: The role of arterial collateral and venous outflow status on the response to intravenous tissue plasminogen activator (IV-tPA) has not been sufficiently clarified in acute major cerebral occlusions.
Elif Sarionder Gencer, Ezgi Yilmaz, Ethem Murat Arsava, Rahsan Gocmen, Mehmet Akif Topcuoglu   +4 more
doaj   +1 more source

On the Fraction of Quasars with Outflows [PDF]

The Astrophysical Journal, 2008
Outflows from active galactic nuclei (AGNs) seem to be common and are thought to be important from a variety of perspectives: as an agent of chemical enhancement of the interstellar and intergalactic media, as an agent of angular momentum removal from the accreting central engine, and as an agent limiting star formation in starbursting systems by ...
Rajib Ganguly, Michael S. Brotherton
openaire   +4 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Measurement of Outflow Facility Using iPerfusion. [PDF]

PLoS ONE, 2016
Elevated intraocular pressure (IOP) is the predominant risk factor for glaucoma, and reducing IOP is the only successful strategy to prevent further glaucomatous vision loss.
Joseph M Sherwood, Ester Reina-Torres, Jacques A Bertrand, Barnaby Rowe, Darryl R Overby   +4 more
doaj   +1 more source

Feedback and Outflows [PDF]

Proceedings of the International Astronomical Union, 2012
AbstractThe low stellar and gas mass fractions, low galaxy-wide star formation rates (relative to galactic dynamical times) and observations of rapid outflows from galaxies, all suggest that stars and active galactic nuclei violently alter the state of the interstellar and even inter-halo gas in galaxies. I argue that the low galaxy wide star formation
openaire   +2 more sources

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Avaliação do fluxo de saída do ventrículo esquerdo em gatos anestesiados submetidos ao pneumoperitônio e à posição deTrendelenburg

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO Objetivou-se avaliar os efeitos do pneumoperitônio e da posição de Trendelenburg sobre o fluxo de saída do ventrículo esquerdo em gatos anestesiados.
M.L. Magalhães, L.T. Nishimura, A.T. Souza, C.F. Magalhães, E. Mattos Júnior, C.S. Honsho, D. Paulino Júnior   +6 more
doaj   +1 more source

Modeling the Endothelial Glycocalyx Layer in the Human Conventional Aqueous Outflow Pathway

Cells, 2022
A layer of proteoglycans and glycoproteins known as glycocalyx covers the surface of the trabecular meshwork (TM), juxtacanalicular tissue (JCT), and Schlemm’s canal (SC) inner wall of the conventional aqueous outflow pathway in the eye.
Alireza Karimi, Mahdi Halabian, Reza Razaghi, J. Crawford Downs, Mary J. Kelley, Ted S. Acott   +5 more
doaj   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source