Results 71 to 80 of about 504,748 (299)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

ALMA Cycle 1 Observations of the HH46/47 Molecular Outflow: Structure, Entrainment and Core Impact

, 2016
We present ALMA Cycle 1 observations of the HH46/47 molecular outflow using combined 12m array and ACA observations. The improved angular resolution and sensitivity of our multi-line maps reveal structures that help us study the entrainment process in ...
Arce, Hector G., Cabrit, Sylvie, Corder, Stuartt A., Dunham, Michael M., Garay, Guido, Mardones, Diego, Noriega-Crespo, Alberto, Offner, Stella S. R., Raga, Alejandro C., Zhang, Yichen   +9 more
core   +3 more sources

Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for Glaucoma [PDF]

, 2016
Nitric oxide (NO) has been shown to lower intraocular pressure (IOP), however its therapeutic effects on outflow physiology are location- and dose-dependent.
Chandrawati, R, Chang, J, Jumeaux, C, Overby, DR, Reina-Torres, E, Sherwood, JM, Stamer, WD, Stevens, MM, Zelikin, AN   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hourglass Magnetic Field of a Protostellar System

Universe
An hourglass-shaped magnetic field pattern arises naturally from the gravitational collapse of a star-forming gas cloud. Most studies have focused on the prestellar collapse phase, when the structure has a smooth and monotonic radial profile.
Shantanu Basu, Xiyuan Li, Gianfranco Bino   +2 more
doaj   +1 more source

USE OF ARTIFICIAL NEURAL NETWORKS FOR MODELING INFLOW AND OUTFLOW AND SALINITY OF LAKE FETZARA IN THE REGION-ANNABA (NE ALGERIA)

Food and Environment Safety, 2022
Lake Fetzara is one of the important lakes in the northeast of Algeria; the water supplying this lake comes from different precipitation and wadis. Moreover, Meboudja wadi constitutes the drainage channel.
Zahra BOUHALI, Larbi DJABRI, Hamza BOUGUERRA, Fatma TRABELSI, Azzedine HANI, Hicham CHAFFAI   +5 more
doaj  

Quantification of the severity of outflow stenosis of hemodialysis fistulas with a pulse- and thrill-based scoring system

BMC Nephrology, 2020
Background Hyper-pulsatility of hemodialysis arteriovenous fistula (AVF) is the basic physical examination finding when there is outflow stenosis. The arm elevation test can also be utilized to detect outflow stenosis.
Matt Chiung-Yu Chen, Mei-Jui Weng, Bai-Chun Chang, Hsiu-Ching Lai, Misoso Yi-Wen Wu, Chia-Yun Fu, Yi-Chun Liu, Wen-Che Chi   +7 more
doaj   +1 more source

Protostellar Jets Enclosed by Low-velocity Outflows

, 2014
A protostellar jet and outflow are calculated for \sim 270 yr following the protostar formation using a three dimensional magnetohydrodynamics simulation, in which both the protostar and its parent cloud are spatially resolved. A high-velocity (\sim100km/
Machida, Masahiro N.
core   +1 more source

SMA outflow/disk studies in the massive star-forming region IRAS18089-1732 [PDF]

, 2004
SMA observations of the massive star-forming region IRAS 18089-1732 in the 1mm and 850mu band reveal outflow and disk signatures in different molecular lines. The SiO(5--4) data show a collimated outflow in the northern direction.
Beuther, H., Ho, P. T. P., Hunter, T. R., Lim, J., Liu, S. -Y., Ohashi, N., Sollins, P., Sridharan, T. K., Su, Y. N., Zhang, Q., Zhao, J. -H.   +10 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source