Results 61 to 70 of about 504,748 (299)
A search for 95 GHz class I methanol masers in molecular outflows
, 2012 We have observed a sample of 288 molecular outflow sources including 123 high-mass and 165 low-mass sources to search for class I methanol masers at 95 GHz transition and to investigate relationship between outflow characteristics and class I methanol ...
Chen, Xi +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Can Protostellar Outflows Set Stellar Masses?
The Astrophysical Journal, 2023 The opening angles of some protostellar outflows appear too narrow to match the expected core–star mass efficiency (SFE) = 0.3–0.5, if the outflow cavity volume traces outflow mass, with a conical shape and a maximum opening angle near 90°.
Philip C. Myers +2 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The location and impact of jet-driven outflows of cold gas: the case of 3C293 [PDF]
, 2013 The nearby radio galaxy 3C293 is one of a small group of objects where extreme outflows of neutral hydrogen have been detected. However, due to the limited spatial resolution of previous observations, the exact location of the outflow was not able to be ...
Emonts, Bjorn +4 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Structured outflow from a dynamo active accretion disc
, 2002 We present an axisymmetric numerical model of a dynamo active accretion disc. If the dynamo-generated magnetic field in the disc is sufficiently strong (close to equipartition with thermal energy), a fast magneto-centrifugally driven outflow develops ...
Brandenburg, Axel +3 more
core +2 more sources
Mass-losing accretion discs around supermassive black holes [PDF]
, 2008 We study the effects of outflow/wind on the gravitational stability of accretion discs around supermassive black holes using a set of analytical steady-state solutions.
A. Merloni +29 more
core +1 more source