Results 41 to 50 of about 580,024 (270)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Robust Algorithms for Change-Point Regressions Using the t-Distribution
Mathematics, 2021 Regression models with change-points have been widely applied in various fields. Most methodologies for change-point regressions assume Gaussian errors. For many real data having longer-than-normal tails or atypical observations, the use of normal errors
Kang-Ping Lu, Shao-Tung Chang
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A RLS-SVM Aided Fusion Methodology for INS during GPS Outages
Sensors, 2017 In order to maintain a relatively high accuracy of navigation performance during global positioning system (GPS) outages, a novel robust least squares support vector machine (LS-SVM)-aided fusion methodology is explored to provide the pseudo-GPS position
Yiqing Yao, Xiaosu Xu
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Geriatric Orthopaedic Surgery & Rehabilitation, 2011 Background: Little is known about readmission rates for total hip and total knee arthroplasty (THA and TKA). Our objective was to examine readmission rates and whether hospitals with high and low readmission rates at baseline remain outliers in subsequent years.
Peter Cram MD, MBA +4 more
openaire +3 more sources
Remote Sensing, 2015 Remote-sensing-derived elevation data sets often suffer from noise and outliers due to various reasons, such as the physical limitations of sensors, multiple reflectance, occlusions and low contrast of texture.
Chuanfa Chen +4 more
doaj +1 more source
OUTLIER IDENTIFICATION ON PENALIZED SPLINE REGRESSION MODELING FOR POVERTY GAP INDEX IN JAVA
Barekeng, 2022 Java is one of the islands in Indonesia which has good establishment acceleration. Even though economic growth was good, poverty is still a serious problem.
Anggita Rizky Fadilah +2 more
doaj +1 more source