Results 61 to 70 of about 580,024 (270)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Mathematics, 2020 Ground level concentrations of nitrogen oxide (NOx) can act as an indicator of air quality in the urban environment. In cities with relatively good air quality, and where NOx concentrations rarely exceed legal limits, adverse health effects on the ...
Javier Martínez Torres +5 more
doaj +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Statistical Computing in Functional Data Analysis: The R Package fda.usc
Journal of Statistical Software, 2012 This paper is devoted to the R package fda.usc which includes some utilities for functional data analysis. This package carries out exploratory and descriptive analysis of functional data analyzing its most important features such as depth measurements ...
Mauel Febrero-Bande +1 more
doaj
Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt +5 more
wiley +1 more source
Separating Effect From Significance in Markov Chain Tests
Statistics and Public Policy, 2020 We give qualitative and quantitative improvements to theorems which enable significance testing in Markov chains, with a particular eye toward the goal of enabling strong, interpretable, and statistically rigorous claims of political gerrymandering.
Maria Chikina +3 more
doaj +1 more source
Comparing probabilistic methods for outlier detection [PDF]
, 1992 This paper compares the use of two posterior probability methods to deal with outliers in linear models. We show that putting together diagnostics that come from the mean-shift and variance-shift models yields a procedure that seems to be more effective ...
Guttman, Irwin, Peña, Daniel
core +1 more source