Results 41 to 50 of about 190,177 (262)
New models for describing outliers in meta‐analysis [PDF]
Research Synthesis Methods, 2015 An unobserved random effect is often used to describe the between‐study variation that is apparent in meta‐analysis datasets. A normally distributed random effect is conventionally used for this purpose. When outliers or other unusual estimates are included in the analysis, the use of alternative random effect distributions has previously been proposed.
Baker, RD, Jackson, D
openaire +3 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Robust principal component analysis for accurate outlier sample detection in RNA-Seq data
BMC Bioinformatics, 2020 Background High throughput RNA sequencing is a powerful approach to study gene expression. Due to the complex multiple-steps protocols in data acquisition, extreme deviation of a sample from samples of the same treatment group may occur due to technical ...
Xiaoying Chen +4 more
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Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Outliers in diffusion-weighted MRI: Exploring detection models and mitigation strategies
NeuroImage, 2023 Diffusion-weighted MRI (dMRI) is a medical imaging method that can be used to investigate the brain microstructure and structural connections between different brain regions. The method, however, requires relatively complex data processing frameworks and
Viljami Sairanen, Jesper Andersson
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FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Abnormal Data Detection Method Based on Ant Colony Algorithm [PDF]
Jisuanji gongcheng, 2016 Since the traditional outlier detection technology based on Omeasure needs to search all paths while detecting abnormal data and it is easy to make misjudgments under the scenario of less amount of data.Hence,it has obvious defects on the efficiency and
CAI Mei,LIU Bo
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Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Outlier Detection and Spatial Analysis Algorithms
CoRR, 2021 Outlier detection is a significant area in data mining. It can be either used to pre-process the data prior to an analysis or post the processing phase (before visualization) depending on the effectiveness of the outlier and its importance. Outlier detection extends to several fields such as detection of credit card fraud, network intrusions, machine ...
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FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source