Results 41 to 50 of about 451,682 (258)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Handling Multicollinearity and Outliers in Logistic Regression Using the Robust Kibria–Lukman Estimator

Axioms
Logistic regression models encounter challenges with correlated predictors and influential outliers. This study integrates robust estimators, including the Bianco–Yohai estimator (BY) and conditionally unbiased bounded influence estimator (CE), with the ...
Adewale F. Lukman, Suleiman Mohammed, Olalekan Olaluwoye, Rasha A. Farghali   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Nonlinear Regressive Maximum Correntropy Extended Kalman Filter With Student’s t-Kernel for GPS Navigation

IEEE Access
State estimation is a critical task across many disciplines, with the extended Kalman filter (EKF) being a widely adopted solution. However, the EKF is built on the mean square error criterion, which limits it to capturing only second-order noise ...
Amita Biswal, Dah-Jing Jwo
doaj   +1 more source

A influência de outliers nos estudos métricos da informação: uma análise de dados univariados

Em Questão, 2018
Este artigo apresenta uma nova fórmula de detecção de outliers via Análise Exploratória de Dados, levando em conta a assimetria dos dados, e também estuda o efeito da remoção dos outliers dos dados originais.
Luís Fernando Maia Lima, Alexandre Masson Maroldi, Dávilla Vieira Odízio da Silva, Carlos Roberto Massao Hayashi, Maria Cristina Piumbato Innocentini Hayashi   +4 more
doaj   +1 more source

A Feature-Cascaded Correntropy LSTM for Tourists Prediction

IEEE Access, 2021
Forecasting the number of tourists is significant to public safety, which can enable the government to control the sudden influx of tourists timely. The temporal dependence (closeness and period), external factors such as holidays, government policy, as ...
Yuehai Chen, Jing Yang, Kun Zhang, Yi Xu, Yuewen Liu   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Outlier detection in multivariate time series via projection pursuit [PDF]

, 2004
This article uses Projection Pursuit methods to develop a procedure for detecting outliers in a multivariate time series. We show that testing for outliers in some projection directions could be more powerful than testing the multivariate series directly.
Peña, Daniel, Tsay, Ruey S., Galeano, Pedro   +2 more
core   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Research on Interval Probability Prediction and Optimization of Vegetation Productivity in Hetao Irrigation District Based on Improved TCLA Model

Agronomy
Vegetation productivity, as an essential global carbon sink, directly influences the variety and stability of ecosystems. Precise vegetation productivity monitoring and forecasting are crucial for the global carbon cycle.
Jie Ren, Delong Tian, Hexiang Zheng, Guoshuai Wang, Zekun Li   +4 more
doaj   +1 more source