Results 51 to 60 of about 364,272 (265)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A Heuristic Approach for Finding Similarity Indexes of Multivariate Data Sets

IEEE Access, 2020
Multivariate data sets (MDSs), with enormous size and certain ratio of noise/outliers, are generated routinely in various application domains. A major issue, tightly coupled with these MDSs, is how to compute their similarity indexes with available ...
Rahim Khan, Muhammad Zakarya, Ayaz Ali Khan, Izaz Ur Rahman, Mohd Amiruddin Abd Rahman, Muhammad Khalis Abdul Karim, Mohd Shafie Mustafa   +6 more
doaj   +1 more source

Outliers and Patterns of Outliers in Contingency Tables with Algebraic Statistics [PDF]

Scandinavian Journal of Statistics, 2012
Abstract.  In this paper, we provide a definition of pattern of outliers in contingency tables within a model‐based framework. In particular, we make use of log‐linear models and exact goodness‐of‐fit tests to specify the notions of outlier and pattern of outliers.
openaire   +4 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Robust Särndal-Type Mean Estimators with Re-Descending Coefficients

Axioms
When extreme values or outliers occur in asymmetric datasets, conventional mean estimation methods suffer from low accuracy and reliability. This study introduces a novel class of robust Särndal-type mean estimators utilizing re-descending M-estimator ...
Khudhayr A. Rashedi, Alanazi Talal Abdulrahman, Tariq S. Alshammari, Khalid M. K. Alshammari, Usman Shahzad, Javid Shabbir, Tahir Mehmood, Ishfaq Ahmad   +7 more
doaj   +1 more source

Outlier-Prone and Outlier-Resistant Distributions [PDF]

Journal of the American Statistical Association, 1976
Abstract Neyman and Scott [3] have considered the ideas of outlier-proneness and outlier-resistance of families of distributions. Under their definition, individual distributions (one-member families) cannot be outlier-prone. This paper offers definitions of outlier-proneness and outlier-resistance that apply to individual distributions, and theorems ...
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Weekly laboratory turn-around time identifies poor performance masked by aggregated reporting

African Journal of Laboratory Medicine, 2020
Background: High-level monthly, quarterly and annual turn-around time (TAT) reports are used to assess laboratory performance across the National Health Laboratory Service in South Africa.
Lindi-Marie Coetzee, Naseem Cassim, Deborah K. Glencross   +2 more
doaj   +1 more source