Results 51 to 60 of about 451,682 (258)

A Flexible Smoother Adapted to Censored Data With Outliers and Its Application to SARS-CoV-2 Monitoring in Wastewater

Frontiers in Applied Mathematics and Statistics, 2022
A sentinel network, Obépine, has been designed to monitor SARS-CoV-2 viral load in wastewaters arriving at wastewater treatment plants (WWTPs) in France as an indirect macro-epidemiological parameter.
Marie Courbariaux, Nicolas Cluzel, Siyun Wang, Vincent Maréchal, Laurent Moulin, Sébastien Wurtzer, Obépine Consortium, Jean-Marie Mouchel, Yvon Maday, Grégory Nuel, Grégory Nuel, Isabelle Bertrand, Mickaēl Boni, Christophe Gantzer, Soizick F. Le Guyader, Yvon Maday, Vincent Maréchal, Jean-Marie Mouchel, Laurent Moulin, Rémy Teyssou, Sébastien Wurtzer   +20 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

k-Means+++: Outliers-Resistant Clustering

, 2020
The k-means problem is to compute a set of k centers (points) that minimizes the sum of squared distances to a given set of n points in a metric space. Arguably, the most common algorithm to solve it is k-means++ which is easy to implement and provides a
Feldman, Dan, Adiel Statman, Dan Feldman, Rozenberg, Liat, Liat Rozenberg, Statman, Adiel   +5 more
core   +1 more source

Araştırmalarda Uygun İstatistiksel Tekniğin Belirlenmesinde Normallik ve Homojenlik İhlallerinin Etkisinin İlgili Literatür Bağlamında Değerlendirilmesi

Journal of Psychometric Research
Araştırmalarda uygun istatistiksel tekniğin belirlenmesi, araştırmanın metodolojik tasarımının yanı sıra analizin amacı, örneklem büyüklüğü ve yapısı, verilerin ve veri setinin karakteristiğinin de dikkate alınmasını gerektiren zorlayıcı bir aşamadır ...
İrem Çelik, Sibel Urlu, Ergul Demir
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Robust Särndal-Type Mean Estimators with Re-Descending Coefficients

Axioms
When extreme values or outliers occur in asymmetric datasets, conventional mean estimation methods suffer from low accuracy and reliability. This study introduces a novel class of robust Särndal-type mean estimators utilizing re-descending M-estimator ...
Khudhayr A. Rashedi, Alanazi Talal Abdulrahman, Tariq S. Alshammari, Khalid M. K. Alshammari, Usman Shahzad, Javid Shabbir, Tahir Mehmood, Ishfaq Ahmad   +7 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source