Results 151 to 160 of about 2,643,650 (314)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Output checking processes: Workshop report
In March 2024 the authors organised a three-day workshop on output checking processes for trusted research environments (TREs). The aim was to explore current practices identify good/best operational practices.
Ritchie, Felix, Green, Elizabeth
core
New Data and Output Concepts for Understanding Productivity Trends [PDF]
The present study is the second is a series of three papers devoted to issues in the measurement of productivity and productivity growth. The contributions of the present paper are three.
William D. Nordhaus
core
Automated Classification of Homeostasis Structure in Input-Output Networks. [PDF]
Bull Math BiolLin X, Antoneli F, Wang Y.
europepmc +1 more source
The State of Stroke Research in Malawi: Results from a Mapping Review Study
Journal of Multidisciplinary HealthcareMemory Lucy Mtambo,1,2 Didjier Danger Masangwi,3 Alpha Omega Soko,4 Thom Kaledzera,5 Fanuel Meckson Bickton,5,6 Mep Coretta Chipeta7 1Department of Clinical Sciences, Malawi University of Science and Technology, Blantyre, Malawi; 2Jeffrey Cheah School of
Mtambo ML +5 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Understanding OECD Output Correlations [PDF]
This paper develops an empirical model of the cross-country variation in bilateral output growth correlations for 17 OECD countries. Consideration is given to the role played by explicit mechanisms for transmitting shocks between countries, such as trade
Graham Voss, Luke Willard, Glenn Otto
core
Optimal Timing of Drain Removal in Patients with Prolonged High Output Following Tissue Expander Breast Reconstruction. [PDF]
Plast Reconstr Surg Glob OpenJadallah E +3 more
europepmc +1 more source