Results 61 to 70 of about 10,030,936 (261)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Fuel Cell Output Current Prediction with a Hybrid Intelligent System
Complexity, 2019 A fuel cell is a complex system, which produces electricity through an electrochemical reaction. For the formal application of control strategies on a fuel cell, it is very important to have a precise dynamic model of it.
José-Luis Casteleiro-Roca +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A high step-up double-dual-boost converter with continuous output current
e-Prime: Advances in Electrical Engineering, Electronics and EnergyAlthough recently proposed double-dual-boost (DDB) DC-DC converters can be used in various applications, they are unable to achieve a higher voltage gain than the conventional DDB converter and typically suffer from a discontinuous output current.
Mohammad Lotfi-Nejad +4 more
doaj +1 more source
New Current-Mode Bandpass Filters Using Three Single-Output ICCIIs
Active and Passive Electronic Components, 2007 New current-mode bandpass filters using three single outputs inverting second generation current conveyors (ICCII) are introduced. The first circuit uses two ICCII+ and one ICCII−, and realizes an inverting bandpass response.
Ahmed M. Soliman
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The Kon-tiki venture [cartographic material] /
, 1950 Map of the Pacific Ocean showing route of Kon-tiki, Kuro Siwo and North Pacific drift, North and South Equatorial currents, Mexico current, Belt of Counter current, Peru or Humboldt's current, and South Pacific Connecting current.; "Map review no. 107, 3
Bureau of Current Affairs (London, England)
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source