Results 81 to 90 of about 3,706,896 (292)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Gradient-Based Approach to Solve Optimal Periodic Output Feedback Control Problems [PDF]

, 1998
We discuss the numerical solution of the output feedback optimal periodic control problem by using a gradient search based optimization approach. Extension of this approach to the simultaneous stabilization of periodic multimodels is also considered. For
Varga, A., Pieters, S,
core  

Static output feedback controller design [PDF]

, 1999
summary:In this paper new necessary and sufficient conditions for static output feedback stabilizability for continuous and discrete time linear time invariant systems have been proposed. These conditions form the basis for the procedure of static output
Veselý, Vojtech, Robert E. Benton, Dirk Smith   +2 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

A performance comparison between two design techniques for non-linear output feedback control

, 2004
For a system possessing a non-linear output feedback normal form, an observer backstepping design is compared to a high gain observer design with respect to non-singular performance cost functional.
French, M, Xie, C
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Synthesis of Adaptive Gain Robust Output Feedback Controllers for a Class of Lipschitz Nonlinear Systems with Unknown Upper Bound of Uncertainty

Journal of Control Science and Engineering, 2012
We propose a new adaptive gain robust output feedback controller for a class of the Lipschitz nonlinear systems with unknown upper bound of uncertainty.
Hidetoshi Oya, Kojiro Hagino
doaj   +1 more source

Modified Output in Response to Clarification Requests and Second Language [PDF]

, 2008
Modified output, second language (L2) learners' reformulation of their own utterances, has been attracting researchers' interest as an important component of learner interactions, and as a manifestation of interlanguage development and psycholinguistic ...
Ogino, Masayoshi
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