Results 161 to 170 of about 385,031 (304)

Emerging Risk: Intranasal Tin Exacerbates Allergic Rhinitis in Humans and Mice

Allergy, EarlyView.
Delgama A. S. M. Nishadhi, Shogo Sumiya, Akira Tazaki, Takumi Kagawa, Mohamed Abdelmoneim, Masafumi Sakashita, Kazuhiro Ogi, Shigeharu Fujieda, Shinichi Iwasaki, Masashi Kato   +9 more
wiley   +1 more source

Autophagy Inhibition by Fangji Huangqi Decoction Enhances Tumor Immunogenicity and Potentiates PD‐1 Blockade

Cancer Science, EarlyView.
In tumor cells, MHC‐I is typically degraded through autophagy, leading to reduced antigen presentation. However, Fangji Huangqi Decoction (FJHQ), acting as an autophagy inhibitor, suppresses lysosomal acidification, which in turn inhibits the degradation of MHC‐I. This results in increased surface expression of MHC‐I on tumor cells.
Yuxiao Jiang, Shiji Zeng, Dingye Wang, Junbo Jiang, Zhenzhen Li, Jingbi Li, Dan Chen, Xu Zhao, Zheng Ying, Yuehua Deng, Qianwei Cai, Silin Mai, Jiayi Zheng, Qiaohong Yang, Fang Liu, Biaoyan Du, Jianyong Xiao, Xiaoyi Liu, Kun Wang   +18 more
wiley   +1 more source

Dissection of the T cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T cell repertoire. [PDF]

Sci Adv
Kehm H, Zens S, Baumann D, Meng Z, de Ru AH, Tjokrodirijo RTN, Vent C, Murawjew O, Braun S, Weiss A, Bieberich F, Konrad A, Lucato F, Kühner J, Minguez SG, Tan CL, Förster JD, Salek M, Riemer AB, Volkmar M, van Veelen P, Poschke I, Offringa R.   +22 more
europepmc   +1 more source

Implications of Maternal Toxicant Effects on Size‐Dependent Fisheries' Management: A Meta‐Analysis

Fish and Fisheries, EarlyView.
Larger, older fish transfer higher mercury and PCB concentrations to their eggs, significantly reducing offspring hatching success, survival and growth rates in contaminated aquatic ecosystems. These findings suggest that the reproductive benefits of big old fat fecund female fish may be compromised by maternal toxicant transfer in polluted waters ...
Brandon M. Sosa, Christopher R. Malinowski, Tomas O. Höök   +2 more
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

A Comprehensive Review of Natural Products Against Allergic Rhinitis and Asthma: From Sensitization to Chronic Remodeling. [PDF]

Int J Mol Sci
Zhang X, Zhou W, Zhang J, Liu C.
europepmc   +1 more source

Blood Immunopathology of Tuberculosis Patients Disrupts Monocyte‐Dependent T‐Cell Activation and Cytokine Expression

Immunology, EarlyView.
TB serum selectively disrupts monocyte‐dependent PHA T cell activation and cytokines associated with proliferation while preserving SEB T cell and Pam3/PHA monocyte cytokine responses. ABSTRACT Pulmonary tuberculosis in humans is characterised by features of immunopathology, which influence both antimycobacterial therapy and the long‐term prognosis. In
Joseph F. Arthur, Hubert S. Ahor, Monika M. Vivekanandan, Difery Minadzi, Augustine Yeboah, Millicent Lamptey, Victoria A. Ofori, Albert D. Kegya, Rejoice Arthur, Linda A. Amoakoa, Ernest Adankwah, Dorcas O. Owusu, Mohammed K. Abass, Fredrick Gyamfi Apraku, Nana K. Ayisi‐Boateng, Seth Adane, Salisu Zakaria, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen   +20 more
wiley   +1 more source

The Experiences of Women With Polycystic Ovary Syndrome of the Healthcare They Receive: A Qualitative Systematic Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Background More than 12% of women worldwide are affected by polycystic ovary syndrome (PCOS), whose symptoms are similar to those of puberty, often leading to delayed diagnosis and missing the opportunity for early intervention. This not only puts PCOS women under physical and mental stress but also reduces their trust in doctors and makes ...
Baoying Zhang, Joan Lalor
wiley   +1 more source

Nociceptor neurons control pollution-mediated neutrophilic asthma. [PDF]

Elife
Wang JC, Kulle A, Crosson T, Reza Nikpoor A, Gupta S, Roger A, Rafei M, Thanabalasuriar A, Talbot S.   +8 more
europepmc   +1 more source

Reproductive parameters of wild and hatchery‐reared sea trout (Salmo trutta m. trutta L.) females from the Łeba River (southern Baltic Sea)

Journal of Fish Biology, EarlyView.
Abstract Sea trout Salmo trutta m. trutta L. has high socioeconomic and ecological importance in the Atlantic region; therefore, stocking hatchery‐reared fish is widely practiced for stock enhancement and recovery of wild populations. In this study, fecundity of wild and stocked hatchery‐reared sea trout sampled from the Łeba River (southern Baltic Sea
Adam M. Lejk, Piotr Hliwa
wiley   +1 more source