Results 71 to 80 of about 385,031 (304)

Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. [PDF]

, 2014
The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal cells using CAR T cells may offer several advantages.
Albelda, Steven M., Antzis, Michael, Cotner, Cody E., Durham, Amy C., Johnson, Laura A., June, Carl H., Kapoor, Veena, Lo, Albert, Majumdar, Rajrupa S., Puré, Ellen, Scholler, John, Solomides, MD, Charalambos C., Sun, Jing, Wang, Liang-Chuan S.   +13 more
core   +2 more sources

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

BIST 100’de Yer Alan Enerji Şirketlerinin Finansal Performans Analizi

Maliye ve Finans Yazıları
Bu çalışmada BIST-100'de yer alan enerji şirketlerinin 2022 ve 2023 finansal performansları CRITIC temelli CODAS yöntemi ile incelenmiştir. Şirketlerin performansları değerlendirilirken 10 kriter göz önünde bulundurulmuş ve çalışma sonuçları tablolar ...
Alper Ova
doaj   +1 more source

Efektivitas Metode Diskusi Kelompok dengan dan tanpa Fasilitator pada Peningkatan Pengetahuan, Sikap dan Motivasi Remaja Tentang Perilaku Seks Pranikah [PDF]

, 2009
Background: The survey result of Indonesian Family Planning Association (PKBI) mentioned that teenagers were started to have sexual relationship when they were 13-18 years old, 60% out of them did not use the contraception, and 85% did that at their own ...
Handayani, Ova Emilia, Budi Wahyuni, Sri
core  

A generic polymer-protein ligation strategy for vaccine delivery [PDF]

, 2016
Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens.
De Geest, Bruno, Fierens, Kaat, Lambrecht, Bart, Lybaert, Lien, Nuhn, Lutz, Schuijs, Martijn, Vanparijs, Nane   +6 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes

Molecules, 2016
To establish peptide vaccine-based cancer immunotherapy, we investigated the improvement of antigenic peptides by encapsulation with pH-sensitive fusogenic polymer-modified liposomes for induction of antigen-specific immunity. The liposomes were prepared
Yuta Yoshizaki, Eiji Yuba, Toshihiro Komatsu, Keiko Udaka, Atsushi Harada, Kenji Kono   +5 more
doaj   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Erhebung von Kupfergesamtgehalten in ökologisch und konventionell bewirtschafteten Böden. Teil 4: – Gesamtgehalte in Böden deutscher Baumobstbaugebiete

Journal für Kulturpflanzen, 2012
Die Auswirkungen dauerhafter Anwendung kupferhaltiger Fungizide auf die Nachhaltigkeit der Bodengüte sind im Rahmen der Europäischen Wirkstoffzulassung Gegenstand eines EU-weiten Programms zur Erfassung der Kupfer­gehalte im Boden geworden.
Thomas Strumpf, Jörn Strassemeyer, Jutta Kienzle, Gerd Palm, Karsten Klopp, Adrian Engel, Heinrich-Ludger Rövekamp, Sandra Müller, Martin Balmer, Jürgen Zimmer, Dieter Felgentreu   +10 more
doaj   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source