Results 111 to 120 of about 102,497 (280)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

The Role of Ovalbumin in Manganese Homeostasis during Chick Embryogenesis: An EPR Spectroscopic Study

Molecules
Ovalbumin (OVA), a protein vital for chick embryo nutrition, hydration, and antimicrobial protection, together with other egg-white proteins, migrates to the amniotic fluid and is orally absorbed by the embryo during embryogenesis.
Ana Vesković, Aleksandra M. Bondžić, Ana Popović Bijelić   +2 more
doaj   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Age-Dependent Effects of Yolkin on Contact Sensitivity and Immune Phenotypes in Juvenile Mice

Molecules
Yolkin, an egg yolk immunoregulatory protein, stimulates the humoral but inhibits the cellular immune response in adult mice. The aim of this investigation was to evaluate the effects of yolkin administration on the immune response using a model of ...
Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Angelika Sysak, Marianna Szczypka, Magdalena Lis, Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Katarzyna Kaleta-Kuratewicz, Aleksandra Zambrowicz, Łukasz Bobak   +11 more
doaj   +1 more source

IgE Antibody Function and Mast Cell Activation to Egg in Children Undergoing Baked and Loosely Cooked Egg Challenges

Allergy, EarlyView.
MAT is dependent on the presence of allergen‐specific IgE and can provide false‐negative results in allergic patients with low allergen‐specific IgE levels. MAT and BAT are moderately correlated. MAT can be used as a surrogate of BAT, when fresh blood is not available or in the case of patients with non‐releaser basophils.
Vikki Houghton, Vasco Claro, Nur Romli, Zainab Jama, Grammatiki Antoneria, Matthew Kwok, Alexandra F. Santos   +6 more
wiley   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Tumor Antigen-Tethered Spiked Virus-Like- Poly(Lactic-Co-Glycolic Acid)-Nanoparticle Vaccine Enhances Antitumor Ability Through Th9 Promotion in Mice

International Journal of Nanomedicine
Ting-Wei Lin,1 Po-Yu Chou,2 Yen-Ting Shen,2 Ming-Thau Sheu,2 Kuo-Hsiang Chuang,3,4 Shyr-Yi Lin,5,6 Chia-Yi Chang1 1Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; 2School of Pharmacy, College of Pharmacy, Taipei Medical ...
Lin TW, Chou PY, Shen YT, Sheu MT, Chuang KH, Lin SY, Chang CY   +6 more
doaj  

Autophagy Inhibition by Fangji Huangqi Decoction Enhances Tumor Immunogenicity and Potentiates PD‐1 Blockade

Cancer Science, EarlyView.
In tumor cells, MHC‐I is typically degraded through autophagy, leading to reduced antigen presentation. However, Fangji Huangqi Decoction (FJHQ), acting as an autophagy inhibitor, suppresses lysosomal acidification, which in turn inhibits the degradation of MHC‐I. This results in increased surface expression of MHC‐I on tumor cells.
Yuxiao Jiang, Shiji Zeng, Dingye Wang, Junbo Jiang, Zhenzhen Li, Jingbi Li, Dan Chen, Xu Zhao, Zheng Ying, Yuehua Deng, Qianwei Cai, Silin Mai, Jiayi Zheng, Qiaohong Yang, Fang Liu, Biaoyan Du, Jianyong Xiao, Xiaoyi Liu, Kun Wang   +18 more
wiley   +1 more source

Enhanced anti-tumor immunotherapy by silica-coated magnetic nanoparticles conjugated with ovalbumin

International Journal of Nanomedicine, 2019
Sung-Ju Lee,1 Jong-Jin Kim,2 Kyung-Yun Kang,3 Man-Jeong Paik,1 Gwang Lee,4 Sung-Tae Yee1 1Department of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of Korea; 2Center for Self-assembly and Complexity, Institute for Basic Science (IBS)
Lee SJ, Kim JJ, Kang KY, Paik MJ, Lee G, Yee ST   +5 more
doaj  

Studies on ovalbumin-s-ovalbumin transformation. Part II. Liberation of carboxyl groups on conversion of ovalbumin to s-ovalbumin.

Agricultural and Biological Chemistry, 1981
NAKAMURA, Ryo, TAKEMORI, Yasuo, SHITAMORI, Shinji   +2 more
openaire   +2 more sources