Results 131 to 140 of about 5,436,787 (348)
BMC Cancer, 2018 Background Approximately 10–15% of ovarian carcinomas (OC) are attributed to inherited susceptibility, the majority of which are due to mutations in BRCA1 or BRCA2 (BRCA1/2).
Robert L. Hollis +10 more
doaj +1 more source
The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance [PDF]
, 2019 Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage ...
Berx, Geert +3 more
core +2 more sources
Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum
Journal of Experimental Medicine, 2019 &NA; Ovarian cancer preferentially metastasizes to the omentum, a fatty tissue characterized by immune structures called milky spots, but the cellular dynamics that direct this tropism are unknown.
WonJae Lee +5 more
semanticscholar +1 more source
Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy
Frontiers in Cell and Developmental Biology, 2020 Ovarian cancer is one of the leading causes of death in patients with gynecological malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy, ovarian cancer disseminates and relapses frequently, with poor prognosis.
Yanfei Yang +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors
Cell Communication and SignalingLiver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 (STK11), is a master kinase that regulates cell migration, polarity, proliferation, and metabolism through downstream adenosine monophosphate-activated protein kinase (AMPK) and AMPK-related ...
Charles B. Trelford, Trevor G. Shepherd
doaj +1 more source
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship [PDF]
, 2007 We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance.
Davey, Ross +2 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Afatinib use in recurrent epithelial ovarian carcinoma. [PDF]
, 2019 •Genomic tumor testing is an important tool in guiding treatment for gynecologic malignancies.•Targetable mutations may lead to new therapies in gynecologic cancer treatment.•Her2/neu mutations in serous ovarian carcinomas can be targeted with ERBB2 ...
Alvarez, Edwin A +3 more
core +1 more source
Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis
Cancer Research, 2020 Frizzled-7 marks platinum-tolerant cancer cells harboring stemness features and altered glutathione metabolism that depend on GPX4 for survival and are highly susceptible to ferroptosis.
Yinu Wang +13 more
semanticscholar +1 more source