Results 71 to 80 of about 86,402 (307)

Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness

Reproductive Biology and Endocrinology, 2011
Background Ovarian cysts are a common cause for gynecological surgery. However, some cysts are a direct result of endocrine disorders and do not require surgery.
Fang Suhua, Zhang Lingyan, Xing Lili, Shu Jing, Huang Hefeng   +4 more
doaj   +1 more source

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

Advanced Science, EarlyView.
Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge, Yuqing Gao, Feifei Du, Chiyuan Ma, Tianxia Xiao, Yali Yang, Xiaohua Lei, Jian V. Zhang   +7 more
wiley   +1 more source

Histological changes within ovarian cortex, oviductal and uterine mucosa in case of ovarian cysts presence in sows.

Folia Histochemica et Cytobiologica, 2009
The aim of study was histological evaluation of oviduct and uterus mucosa in case of cystic ovarian degeneration in sows. Materials for evaluations were received after slaughtering of 294 sows at age of 2-5 years. Sows were eliminated breeding and culled
Katarzyna Szulańczyk
doaj   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source

Innovation of LESS-OPEN concept and its application and prospect in ovarian cystectomy

陆军军医大学学报
Ovarian cysts are one of the most common gynecological diseases, and laparoscopic surgery has been considered as the main approach for treating benign ovarian tumors.
WANG Yanzhou, TAN Wenwei
doaj   +1 more source

Management of ovarian cysts in infants

Journal of Research in Medical Sciences, 2015
To discuss the experience of diagnosis and treatment of ovarian cyst in infants.A retrospective review was conducted on 20 infants who suffered from ovarian cyst.There were no dysplasia ovarian was found in children which were preoperatively diagnosed simplex cyst.
Qin Xin-ke, Yan Xueqiang, Yu Lei, Zheng Nannan, Yang Jun, Bian Hongqiang, Lu Wei, Duan Xufei   +7 more
openaire   +4 more sources

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu, Hongchao He, Shilei Qiao, Yifan Shao, Lurong Wang, Zhengkui Zhang, Long Zhang, Fangfang Zhou   +7 more
wiley   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

Ovarian hyperstimulation syndrome following surgical removal of a complete hydatidiform mole: a case report

Journal of Medical Case Reports, 2019
Background Generally, ovarian hyperstimulation syndrome develops after superovulation caused by ovulation-inducing drugs in infertile patients. However, ovarian hyperstimulation syndrome associated with natural pregnancy is rare, and most cases of ...
Hiroaki Tsubokura, Yohei Ikoma, Takuya Yokoe, Tomoo Yoshimura, Katsuhiko Yasuda   +4 more
doaj   +1 more source