Results 71 to 80 of about 218,391 (348)

SV2B Promotes the Progression of TFE3‐Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF‐κB Subunits

Advanced Science, EarlyView.
TFE3‐rearranged renal cell carcinoma (TFE3‐RCC) lacks clearly defined diagnostic and therapeutic targets. SV2B, a TFE3 target gene, promotes TFE3‐RCC progression by activating the NF‐κB pathway. Targeted inhibition with padsevonil or Withaferin A effectively suppresses tumor progression.
Huayi Feng, Zhuang Xiong, Shaoqing Yu, Junxiao Liu, Shouqing Cao, Kan Liu, Xing Huang, Lequan Wen, Baojun Wang, Qingbo Huang, Tiejun Pan, Xu Zhang, Xin Ma, Xiubin Li   +13 more
wiley   +1 more source

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

Ovarian cysts and cyclic hormone replacement therapy: is there an association?

Acta Obstetricia et Gynecologica Scandinavica, 1997
Objectives. To evaluate whether there may be an association between postmenopausal ovarian cysts and hormone replacement therapy. Methods. The study comprised 564 consecutive, asymptomatic, postmenopausal women who were referred for routine, transvaginal
Itai Bar‐Hava, Raoul Orvieto, David Vardimon, Yoram Manor, Ariel Weissman, Roni Nelinger, Zion Ben‐Rafael   +6 more
doaj   +1 more source

Huge bilateral ovarian cysts in adulthood as the presenting feature of Van Wyk Grumbach syndrome due to chronic uncontrolled juvenile hypothyroidism

Indian Journal of Endocrinology and Metabolism, 2013
Juvenile primary hypothyroidism causing cystic ovaries and pseudoprecocious puberty (Van-Wyk Grumbach syndrome (VWGS)) is well documented in literature. There are only a few reports of primary hypothyroidism presenting as ovarian cysts in adults. Here we
K S Shivaprasad, Deep Dutta, Rajesh Jain, Manoj Kumar, Indira Maisnam, Dibakar Biswas, Sujoy Ghosh, Satinath Mukhopadhyay, Subhankar Chowdhury   +8 more
doaj   +1 more source

Ovariële cysten bij de zeug: een multifactoriële aandoening met een weerslag op de vruchtbaarheid [PDF]

, 2011
Ovarian cysts are an important cause of reduced reproductive performance in gilts and sows. The formation of follicular cysts, although not completely elucidated yet, is associated with a deficiency in LH release and the continuous growth of follicles ...
Beek, Josine, de Jong, Ellen, de Kruif, Aart, Maes, Dominiek, Van Soom, Ann   +4 more
core   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

The influence of ovarian cyst type and size on ovarian reserve markers: implications for fertility counseling and preservation strategy

Frontiers in Endocrinology
BackgroundOvarian cysts are common in reproductive-aged women and may affect ovarian reserve, thereby impacting fertility potential. This study aimed to evaluate the differential impact of various ovarian cyst types and sizes on ovarian reserve markers ...
Xingyu Sun, Doudou Liu, Zijing Guo, Lijuan He, Shaohua Wang   +4 more
doaj   +1 more source

Endometriosis: 10 keys points for MRI [PDF]

, 2015
Endometriosis is a chronic disease and a clinical problem in women of fertile age, with a high impact on quality of life, work productivity and health care management.
ANASTASI, Emanuela, BALLESIO, Laura, BERNARDO, SILVIA, FUGGETTA, ELIANA, GIANCOTTI, Antonella, MANGANARO, Lucia, PORPORA, Maria Grazia, SALDARI, MATTEO, SOLLAZZO, PAOLO, VINCI , VALERIA   +9 more
core   +1 more source

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, Jane Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

Ovarian Ectopic Pregnancy in Adolescence [PDF]

, 2015
Ovarian pregnancy is one of the rarest types of extrauterine pregnancy. Its preoperative diagnosis remains a challenge since it presents quite similarly to tubal pregnancy and complicated ovarian cysts.
Barros, C, Biscaia, I, Gonçalves Andrade, A, Marques, C, Martins, I, Rocha, S, Simões, M   +6 more
core   +2 more sources