Results 81 to 90 of about 468,992 (283)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Benign ovarian cysts and breast cancer risk

, 2006
Benign ovarian cysts have been suggested to influence breast cancer risk. To provide a comprehensive picture of the relation between ovarian cysts and breast cancer, we analyzed the data of 3 case-control studies conducted in northern Italy and the Swiss
GIACOSA A, LA VECCHIA C, BOSETTI C, LEVI F, FRANCESCHI S, MONTELLA M, TALAMINI R, SCOTTI L, NEGRI E   +8 more
core   +2 more sources

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Functional ovarian cysts in girls [PDF]

, 2003
Ovarian masses may result from functional (nonneoplastic) cysts or benign or malignant neoplasms. In 1973, the World Health Organisation classified ovarian neoplasms into nine major categories and 26 subtypes, based on histologic cell type and benign ...
Basevičienė, Ingrida, Labanauskas, Liutauras, Martinkienė, Inga, Basevičius, Algidas   +3 more
core  

Origin of ovarian cancer from benign cysts

, 2001
In a case-control study of 1031 epithelial ovarian cancers and 2311 controls conducted in Italy, 56 cases and 116 controls reported history of benign ovarian cysts, corresponding to a relative risk of 1.3 (95% confidence interval = 0.9-1.8).
Canzonieri V, La Vecchia C, Dal Maso L, Talamini R, C. La Vecchia, L. Dal Maso, V. Canzonieri, R. Talamini, S. Franceschi, Franceschi S   +9 more
core   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

Analysis of gonadocorticoids profile in canine patients diagnosed with ovarian cysts

Cluj Veterinary Journal
Veterinarians can obtain a more comprehensive understanding of the progression of ovarian cystic pathology in dogs by assessing hormonal levels. This study aimed to examine the gonadocorticoid profile of dogs diagnosed with ovarian cysts and compare ...
Zoltán-Miklós GÁL , Ana Hiruta, Alexandru-Raul POP , Alexandra IRIMIE, Ioan- Ștefan GROZA   +4 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

17β-Hydroxysteroid dehydrogenase type I and aromatase in ovarian cortical inclusion cysts

Endocrine Connections
Previous evidence suggests a link between the ovarian surface epithelium and cortical inclusion cysts and the origin of epithelial ovarian cancer.
Enrique Pedernera, Flavia Morales-Vásquez, Delia Pérez-Montiel, Elizabeth Rendon, Esteban Mena, Laura Diaz-Cueto, Carmen Mendez   +6 more
doaj   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source