Results 71 to 80 of about 1,602 (213)

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness

Reproductive Biology and Endocrinology, 2011
Background Ovarian cysts are a common cause for gynecological surgery. However, some cysts are a direct result of endocrine disorders and do not require surgery.
Fang Suhua, Zhang Lingyan, Xing Lili, Shu Jing, Huang Hefeng   +4 more
doaj   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

The comparative study of Yaz and Ovocept-ld on patients with simple ovarian cysts referring to Iran-Isfahan Shariati Hospital

Advanced Biomedical Research, 2014
Background: Functional ovarian cysts include follicular, corpus luteum, and theca lutein cysts are the most common adnexal masses (about 50%) in women of reproductive age.
Soheyla Riahinejad, Azam Foroughi Pour, Leila Dehghani, Saadat Hajizadeh   +3 more
doaj   +1 more source

TREM2+ Macrophages Promote Immune Evasion in Endometriosis Through BAG3‐Associated Regulation of CD8+ T Cell Autophagy

Advanced Science, EarlyView.
TREM2+ macrophages are enriched in endometriosis and suppress CD8+ T cell function through SPP1–CD44 communication and BAG3‐associated autophagy regulation. Genetic TREM2 deficiency restores cytotoxic lymphocyte activity, whereas antibody‐mediated TREM2 blockade reduces ectopic lesion growth, highlighting TREM2 as a potential non‐hormonal therapeutic ...
Ming Yuan, Xue Jiao, Le Xu, Qianhui Ren, Shuang Wang, Zhaoyang Zhong, Na Li, Qiuju Li, Xiaoli Meng, Guoyun Wang   +9 more
wiley   +1 more source

Incidental Discovery of Giant Ovarian Cysts During Autopsy. Case Analysis and Literature Review

Acta Medica Lituanica
Background: Cysts are called giant when they are >10 cm in diameter. Today the frequency of giant ovarian cysts is decreasing due to good diagnostic methods and regular gynecological examination.
Justė Kazlauskaitė, Sigitas Chmieliauskas, Diana Vasiljevaitė, Sigitas Laima   +3 more
doaj   +1 more source

Ovarian cysts, vaginal bleeding and hypothyroidism in a 4-year-old female with Down Syndrome: A case of Van Wyk-Grumbach Syndrome

Journal of Pediatric Surgery Case Reports, 2017
Van Wyk-Grumbach Syndrome (VWGS) is a constellation of symptoms including precocious puberty without adrenarche, delayed bone age, ovarian cysts, and hypothyroidism.
Suniah S. Ayub, Ana Ruzic, Janice A. Taylor   +2 more
doaj   +1 more source

Male reproductive system in stenopodidean shrimps: Unveiling basal reproductive traits in shrimp‐like Pleocyemata (Stenopodidae and Spongicolidae)

The Anatomical Record, EarlyView.
Abstract Stenopodidea represents one of the basal lineages within Pleocyemata, yet the male reproductive system (MRS) of this group remains poorly understood, with limited information available regarding its morphology and function. This study provides the first detailed description of the MRS in four stenopodidean shrimp species from two families ...
Caio Santos Nogueira, Lucas Rezende Penido Paschoal, Fernando José Zara   +2 more
wiley   +1 more source

Histopathologic and Sonographic Analysis of Laparoscopic Removal Ovarian Nonendometriotic Cyst: The Evaluating Effects on Ovarian Reserve

Acta Medica Iranica, 2014
Currently, laparoscopic cystectomy is the first-line therapy for ovarian benign cysts that are resistant to current therapies. There are different studies that point to ovarian reserve damage due to laparoscopic cystectomy. In this study, we evaluate the
Soheila Sarmadi, Farahnaz Sadat Ahmadi, Shahram Ejtemaei Mehr, Azizeh Ghaseminejad, Kazem Mohammad, Sepideh Nekuie, Soleiman Abbasi, Mehrdad Karimi, Fereshteh Gharibpoor, Zahra Elahipanah   +9 more
doaj  

Incidence of ovarian cysts in adolescents girls complaining of lower abdominal pain and/or menstrual disturbance in Zagazig University Hospital [PDF]

Zagazig University Medical Journal
Background: Ovarian cysts are a common gynecological problem that affects a high percentage of females, particularly during puberty. While majority of ovarian cysts are asymptomatic and frequently resolve spontaneously, some may become large causing ...
Badeea Soliman, Hussein Abdeldayem, Dalia Hamada, Mohamed Ramadan   +3 more
doaj   +1 more source