Results 71 to 80 of about 2,535,326 (289)

Ovarian Crohn's disease [PDF]

Journal of Crohn's and Colitis, 2010
Dear Sir, Crohn's disease is a chronic inflammatory disorder that may involve any portion of the gastrointestinal tract. Predominant symptoms include abdominal pain, diarrhea and weight loss. The hallmark of Crohn's disease is bowel inflammation with fistula or stricture formation.
A. Ouakaa-Kchaou, H. Elloumi, A. Kochlef, D. Gargouri, J. Kharrat, A. Kilani, A. Ghorbel   +6 more
openaire   +1 more source

Socioeconomic Burden of Ovarian Cancer in 11 Countries

JCO Global Oncology
PURPOSEOvarian cancer remains among the most aggressive tumors with the lowest survival probability. Projections are that ovarian cancer will claim more than 8 million lives between 2022 and 2050 without better prevention or control measures.METHODSWe ...
Brian Hutchinson, Mikis Euripides, Frances Reid, Gavin Allman, Lily Morrell, Garrison Spencer, Andre Ilbawi, Filip Meheus, Hesham Gaafar, Raffaella Casolino   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Ovarian cancer symptom awareness and anticipated delayed presentation in a population sample [PDF]

, 2014
Background While ovarian cancer is recognised as having identifiable early symptoms, understanding of the key determinants of symptom awareness and early presentation is limited.
White, Ceri, Alice E Simon, Brain, Kate E, Smits, Stephanie, White, C., Brain, Katherine, Hanson, Jane, Brain, K.E., Neal, RD, Grp, ICBPM2W, Lindsay J Forbes, Kate E Brain, on behalf of the ICBP Module 2 Working Group,, Neal, Richard D., Robbe, IJ, Hanson, J, Robbe, Iain, Roberts, C, Smits, S., Smits, S M, Hanson, J., Robbe, I.J., Simon, A.E., Iain J Robbé, John Steward, Roberts, Chris, Brain, KE, Stephanie Smits, Forbes, Lindsay J., Jane Hanson, Roberts, C., Forbes, LJ, Richard D Neal, Simon, Alice E, Ceri White, Forbes, L.J., Chris Roberts, Robbé, Iain J., Steward, John, White, C, Simon, Alice E., Steward, J., Neal, R.D., Simon, AE, Forbes, Lindsay, Forbes, Lindsay J.L., Smits, S, Brain, Kate E., Steward, J, Neal, Richard   +49 more
core   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Ovarian cancer screening in the general population. [PDF]

, 2007
Despite significant improvements in therapy, ovarian cancer continues to be a leading cause of death amongst women with gynaecological malignancies. Advanced stage at diagnosis is thought to be a major contributor to mortality.
Menon, U., Menon, Usha Dr
core  

Targeted anti-vascular therapies for ovarian cancer: current evidence [PDF]

, 2013
Ovarian cancer presents at advanced stage in around 75% of women, and despite improvements in treatments such as chemotherapy, the 5-year survival from the disease in women diagnosed between 1996 and 1999 in England and Wales was only 36%.
Mcneish, I., Gore, M., M Hall, Gore, M, C Gourley, Hall, M, Kaye, S, Gourley, C., Ledermann, J, McNeish, I, Jayson, G.; id_orcid, Gourley, C, G Jayson, Jayson, G., Kaye, S., Rustin, G, M Gore, J Ledermann, S Kaye, Perren, T, I McNeish, Hall, M., G Rustin, Rustin, G., Perren, T., T Perren, Jayson, G, Ledermann, J.   +27 more
core   +1 more source

Changes in Rehmanniae Radix processing and their impact on ovarian hypofunction: potential mechanisms of action

Frontiers in Pharmacology
ObjectiveThis study evaluates the research developments concerning Rehmanniae Radix in ovarian hypofunction diseases. It explores the processing methods of Rehmanniae Radix, the variations in its compounds before and after processing, the mechanism of ...
Han-Zhi Zhong, Jing Mo, Yan-Xin Li, Mao-Ya Li, Shao-Bin Wei   +4 more
doaj   +1 more source